National Toxicology Program

CASRN: 72-20-8

Formula: C12-H8-CL6-O

Synonyms/Common Names:

• (1AALPHA,2BETA,2ABETA,3ALPHA,6ALPHA,6ABETA,7BETA,7AALPHA)-2,7:3,6-DIMETHANONAPHTH(2,3-B)OXIRENE, 3,4,5,6,9,9-HEXACHLORO-1-A,2,2A,3,6,6A,7,7A-OCTAHYDRO- (9CI)

Known Uses:

PESTICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00157) Completed 
  • NTIS No. PB288461  (Peer Review 08/31/1978)
    Citation: Bioassay of Endrin for Possible Carcinogenicity (CAS No. 72-20-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00157) Completed 
  • NTIS No. PB288461  (Peer Review 08/31/1978)
    Citation: Bioassay of Endrin for Possible Carcinogenicity (CAS No. 72-20-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,2.5,80, M: 0,2.5,20 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00157) Report Complete 
  • TR-012 (NTIS No. PB288461)  (Peer Review 08/31/1978)
    Bioassay of Endrin for Possible Carcinogenicity (CAS No. 72-20-8)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR&FM: 0,2.5,5, FR: 0,3,6 (AVG), MM: 0,1.6,3.2 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (177824) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (242024) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  •  Negative 
• Salmonella  (299797) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative