National Toxicology Program

CASRN: 50-81-7

Formula: C6 H8 O6

Synonyms/Common Names:

• 3-OXO-L-GULOFURANOLACTONE
• VITAMIN C

Known Uses:

GRAS FOOD ADDITIVE, USED IN COSMETICS, STAIN REMOVERS, PLASTICS, PHOTOGRAPHY AND WATER TREATMENT

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C54808) Completed 
  • NTIS No. PB83-201194  (Peer Review 06/16/1982)
    Citation: Carcinogenesis Bioassay of L-Ascorbic Acid (Vitamin C) (CAS No. 50-81-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C54808) Completed 
  • NTIS No. PB83-201194  (Peer Review 06/16/1982)
    Citation: Carcinogenesis Bioassay of L-Ascorbic Acid (Vitamin C) (CAS No. 50-81-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,25000,100000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C54808) Report Complete 
  • TR-247 (NTIS No. PB83-201194)  (Peer Review 06/16/1982)
    Carcinogenesis Bioassay of L-Ascorbic Acid (Vitamin C) (CAS No. 50-81-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,25000,50000 PPM/50 PER GROUP

Special Studies

• C. elegans  (S0872) Completed 
  • Nematode: C. elegans
  • Dose: Repro: 0,.25,.32,.4,.5,.63,.79,1,1.3,1.6,2,2.5mM 03/05/07 Feed: 0,.4,.5,.63,.79,1.0,1.3,1.6,2.0,2.5,3.2,4.0 mM 3/28/07 Growth: 0,.63,.79,1.0,1.3,1.6,2.0,2.5,3.2,4.0,5.0,6.3 mM 04/01/07

Genetic Toxicology

• Chromosome Aberrations  (592095) Completed 
  • Mice
  • Chromosome Aberation  Positive 
• In Vitro Cytogenetics (CA/SCE)  (339872) Completed 
  • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (395917) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (936928) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (938108) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (802020) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Inconclusive 
• Micronucleus  (521899) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Positive 
• Salmonella  (065391) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative 
• Salmonella  (070079) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Weakly Positive 
• Sister Chromatid Exchanges  (592095) Completed 
  • Mice
  • Sister Chromatid  Positive 

Organ Systems Toxicity

• Total Reproductive Capacity  (TRC98003) Completed 
  • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns ofFemale Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
  • F Mice
  • Mice Female Negative