National Toxicology Program

CASRN: 303-47-9

Formula: C20 H18 CL N O6

Synonyms/Common Names:

• L-PHENYLALANINE, N-((5-CHLORO-3,4-DIHYDRO-8-HYDROXY-3-METHYL-1-OXO-1H-2-BENZOPYRAN-7-YL)CARBONYL)-, (R)- (9CI)

Known Uses:

NATURALLY OCCURRING FUNGAL TOXIN; CONTAMINANT IN CORN, PEANUTS, STORAGE GRAINS, COTTONSEED, MEATS, DRIED FISH,AND NUTS.

Short-Term Toxicity

• 14-Day (Gavage)  (C56586) Completed 
  • NTIS No. PB90-219478  (Peer Review 04/18/1988)
    Citation: Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
• 13-Week (Gavage)  (C56586) Completed 
  • NTIS No. PB90-219478  (Peer Review 04/18/1988)
    Citation: Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
  • Dose: 0,30,200 MG/KG/30 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C56586) Report Complete 
  • TR-358 (NTIS No. PB90-219478)  (Peer Review 04/18/1988)
    Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Dose: R: 0, 21, 70, 210 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (943337) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Salmonella  (683918) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative