National Toxicology Program

CASRN: 78-84-2

Formula: C4 H8 O

Synonyms/Common Names:

• 2-METHYLPROPANAL (9CI)

Known Uses:

SYNTHESIS OF PANTOTHENIC ACID, CELLULOSE ESTERS, PERFUMES, FLAVORS, AND GASOLINE ADDITIVES. CHEMICAL INTERMEDIATE. (TDB)

Short-Term Toxicity

• 14-Day (Inhalation)  (C60968A) Completed 
  • NTIS No. PB99-134785
    Citation: Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CAS No. 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Inhalation)  (C60968A) Completed 
  • NTIS No. PB99-134785
    Citation: Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CAS No. 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,500,8000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C60968B) Report Complete 
  • TR-472 (NTIS No. PB99-134785)  (Peer Review 12/12/1996)
    Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CAS No. 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R&M: 0, 500, 1000, OR 2000 PPM (50/SEX/SPECIES/GROUP)

Genetic Toxicology

• Chromosome Aberrations  (A27944) Completed 
  • Mice
  • Chromosome Aberation  Positive 
• In Vitro Cytogenetics (CA/SCE)  (984070) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (112954) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (927534) Completed 
  •  Positive 
• Micronucleus  (A56966) Completed 
  • Rats: F344
  • Male Negative 
• Micronucleus  (A60444) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A73413) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (700142) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (941876) Completed 
  •  Inconclusive 

Organ Systems Toxicity

• Immunotoxicity (Topical Application)  (IMM87038) Completed 
  • F Mice: B6C3F1
  • Dose: SENSITIZATION: 0,3,10,30%; CHALLENGE: 30%; POSITIVE CONTROL: 0.5% DNFB.