Testing Information

Testing Status of Agents at NTP

Citral

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http://ntp.niehs.nih.gov/go/TS-10251-N

CASRN: 5392-40-5

Formula: C10 H16 O

Synonyms/Common Names:

  • 3,7-DIMETHYL-2,6-OCTADIENAL (9CI)

Known Uses:

PERFUMERY, FLAVORING AGENT, INTERMEDIATE IN VITAMIN A MANUFACTURE, MAIN CONSTITUENT OF OIL OF LEMON, ORANGE

Short-Term Toxicity

  • 2-WEEK (Gavage)  (C56348B) Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.625, 1.25, AND 2.5% BY WEIGHT
  • 2-WEEK (Microencapsulation in Feed)  (C56348C) Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.625, 1.25, 2.5, 5.0, AND 10% BY WEIGHT/5 PER GROUP
  • 13-WEEK (Microencapsulation in Feed)  (C56348A) Completed 
    • NTIS No. PB2003-103040  (Peer Review 05/03/2001)
      Citation: Toxicology and Carcinogenesis Studies of Citral (Microencapsulated) (CAS No. 5392-40-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3900, 7800, 15600, OR 31300 PPM

Long-Term Carcinogenicity

  • 2-YEAR (Microencapsulation in Feed)  (C56348A) Report Complete 
    • TR-505 (NTIS No. PB2003-103040)  (Peer Review 05/03/2001)
      Toxicology and Carcinogenesis Studies of Citral (Microencapsulated) (CAS No. 5392-40-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0 (UNTREATED), 0 (VEHICLE), 1000, 2000, OR 4000 PPM M: 0 (UNTREATED), 0 (VEHICLE), 500, 1000, OR 2000 PPM

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0087) Completed 
    • Citation: DILIBERTO, J.J., USHA, G. & BIRNBAUM, L.S., DISPOSITION OF CITRAL IN THE MALE FISCHER RATS, DRUG MET & DISP, 16(5):721-727, 1988.
    • M Rats: F344; M Rats: F344
  • Metabolism (Gavage)  (S0002) Completed 
    • Citation: "METABOLISM OF CITRAL, AN ALPHA,BETA-UNSATURATED ALDEHYDE, IN MALE 344 RATS", JJ DILIBERTO, P. SRINIVAS, D. OVERSTREET, G. USHA,LT BURKA, AND LS BIRNBAUM; DRUG METABOLISM & DISPOSITION, VOL,18,NO.6,866-875, 1990.
    • M Rats: F344
    • Dose: 5, 500 MG/KG

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (881385) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Micronucleus  (A66944) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A84250) Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (B84250) On Test 
    • Mice: B6C3F1
  • Salmonella  (110259) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 

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Web page last updated on November 24, 2008