National Toxicology Program

CASRN: 2425-85-6

Formula: C17-H13-N3-O3

Synonyms/Common Names:

• 1-((4-METHYL-2-NITROPHENYL)AZO)-2-NAPHTHALENOL
• RED 3, C.I. PIGMENT

Known Uses:

USED IN MANUFACTURE OF PAINTS, INKS, PLASTICS, RUBBER. (TDB)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C60366) Completed 
  • NTIS No. PB92-191634  (Peer Review 07/09/1991)
    Citation: Toxicology and Carcinogenesis Studies of C.I. Pigment Red 3 (CAS No. 2425-85-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C60366) Completed 
  • NTIS No. PB92-191634  (Peer Review 07/09/1991)
    Citation: Toxicology and Carcinogenesis Studies of C.I. Pigment Red 3 (CAS No. 2425-85-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 3000, 6000, 12500, 25000, 50000 PPM (10 PER GROUP)

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C60366) Report Complete 
  • TR-407 (NTIS No. PB92-191634)  (Peer Review 07/09/1991)
    Toxicology and Carcinogenesis Studies of C.I. Pigment Red 3 (CAS No. 2425-85-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Some Evidence 
  • Male Mice Some Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0, 6000, 12500, 25000; M: 0, 12500, 25000, 50000 PPM (60 PER GROUP)

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0030) Completed 
  • Citation: EL DAREER, S.M., TILLERY, K.F. & HILL, D.L.: INVESTIGATIONS ON THE DISPOSITION OF ORAL DOSES OF SOME WATER-INSOLUBLE PIGMENTS, BULL ENVIRON CONTAM TOXICOL, 32:171-174, 1984.
  • Rats
  • Dose: 11.8 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (069775) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Salmonella  (945354) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive