National Toxicology Program

CASRN: 106-87-6

Formula: C8 H12 O2

Synonyms/Common Names:

• 3-OXIRANYL-7-OXABICYCLO(4.1.0)HEPTANE (9CI)
• VINYLCYCLOHEXENE DIEPOXIDE
• 1-VINYL-3-CYCLOHEXENE DIOXIDE

Known Uses:

ORGANIC SYNTHESIS. REACTIVE DILUENT. CHEMICAL INTERMEDIATE. (TDB)

Short-Term Toxicity

• 14-Day (Topical Application)  (C60139A) Completed 
  • NTIS No. PB90-219957  (Peer Review 03/13/1989)
    Citation: Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CAS No. 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Topical Application)  (C60139A) Completed 
  • NTIS No. PB90-219957  (Peer Review 03/13/1989)
    Citation: Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CAS No. 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,62.5,1000 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C60139A) Report Complete 
  • TR-362 (NTIS No. PB90-219957)  (Peer Review 03/13/1989)
    Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CAS No. 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0, 50, 100, M: 0, 25, 50, 100 MG/ML/60 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage; Topical Application; Gavage; Topical Application)  (S0138) Completed 
  • M/F Rats; M/F Rats; M/F Mice; M/F Mice
  • Dose: R: .15, 30 MG/RAT M: 0, 2.5,5, 10 MG/MOUSE

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (629851) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (496867) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (708500) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive