National Toxicology Program

CASRN: 59820-43-8

Formula: C10-H14-N2-O5

Synonyms/Common Names:

• 2-((2-(2-HYDROXYETHOXY)-4-NITROPHENYL)AMINO)-ETHANOL
• YELLOW 4, HC

Known Uses:

IN SEMI-PERMANENT HAIR DYE FORMULATIONS (HSDB 1990).

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C56019) Completed 
  • NTIS No. PB93-123883  (Peer Review 07/09/1991)
    Citation: Toxicology and Carcinogenesis Studies of HC Yellow 4 (CAS No. 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C56019) Completed 
  • NTIS No. PB93-123883  (Peer Review 07/09/1991)
    Citation: Toxicology and Carcinogenesis Studies of HC Yellow 4 (CAS No. 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,2500,20000 M: 0,5000,80000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C56019) Report Complete 
  • TR-419 (NTIS No. PB93-123883)  (Peer Review 07/09/1991)
    Toxicology and Carcinogenesis Studies of HC Yellow 4 (CAS No. 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: MR: 0,0.25,0.5%, FR&M: 0,0.5,1.0%/70 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (203825) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (048811) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Salmonella  (764380) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive