National Toxicology Program

CASRN: 98-00-0

Formula: C5-H6-O2

Synonyms/Common Names:

• 2-FURANMETHANOL (9CI)
• FURYLCARBINOL
• 2-HYDROXYMETHYLFURAN

Known Uses:

SOLVENT FOR ETHERS AND ESTERS. IN MANUFACTURE OF PHENOLIC AND FURAN RESINS. CHEMICAL INTERMEDIATE. WETTING AGENT. LIQUID PROPELLANT. FLAVORING AGENT, OBTAINED FROM PROCESSING CORNCOBS, COFFEE BEANS

Short-Term Toxicity

• 2-WEEK (Inhalation)  (C56224B) Completed 
  • NTIS No. PB99-151482
    Citation: Toxicology and Carcinogenesis Studies of Furfural Alcohol (CAS No. 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0, 16, 31, 63, 125 AND 250 PPM (5/S/S)
• 13-WEEK (Inhalation)  (C56224B) Completed 
  • NTIS No. PB99-151482
    Citation: Toxicology and Carcinogenesis Studies of Furfural Alcohol (CAS No. 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0, 2, 4, 8, 16 OR 32 PPM / (10/S/S)

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C56224C) Report Complete 
  • TR-482 (NTIS No. PB99-151482)  (Peer Review 12/10/1997)
    Toxicology and Carcinogenesis Studies of Furfural Alcohol (CAS No. 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice No Evidence 
  • Dose: R&M: 0, 2, 8, OR 32 PPM (50/SEX/SPECIES/GROUP)

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0094) Completed 
  • Citation: NOMEIR, A.A., SILVEIRA, D.M., MCCOMISH, M.F. & CHADWICK, M.: COMPARATIVE METABOLISM & DISPOSITION OF FURFURAL & FURFURYL ALCOHOL IN RATS, DRUG MET. & DISP., 20(2):198-204, 1992.
  • M Rats: F344
• Toxicokinetic Study (Inhalation)  (S0781) Completed 
  • M/F Rats: F344; M/F Mice: B6C3F1
  • Dose: 0, 2, 8, & 32 ppm

Genetic Toxicology

• Chromosome Aberrations  (150910) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (799233) Completed 
  • Chromosome Aberation Inconclusive 
  • Sister Chromatid Exchange Positive 
• Micronucleus  (A08423) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (709717) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Sister Chromatid Exchanges  (150910) Completed 
  • Mice
  • Sister Chromatid  Negative