National Toxicology Program

CASRN: 91-93-0

Formula: C16-H12-N2-O4

Synonyms/Common Names:

• 4,4'-DIISOCYANATO-3,3'-DIMETHOXY-1,1'BIPHENYL (9CI)

Known Uses:

POLYURETHANE ELASTOMERS; ADHESIVES

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02175) Completed 
  • NTIS No. PB290154  (Peer Review 08/31/1978)
    Citation: Bioassay of 3,3'-Dimethoxybenzidine-4,4'-diisocyanate for Possible Carcinogenicity (CAS No. 91-93-0)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02175) Completed 
  • NTIS No. PB290154  (Peer Review 08/31/1978)
    Citation: Bioassay of 3,3'-Dimethoxybenzidine-4,4'-diisocyanate for Possible Carcinogenicity (CAS No. 91-93-0)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,800,5000, M: 0,215,4640 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02175) Report Complete 
  • TR-128 (NTIS No. PB290154)  (Peer Review 08/31/1978)
    Bioassay of 3,3'-Dimethoxybenzidine-4,4'-diisocyanate for Possible Carcinogenicity (CAS No. 91-93-0)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,22000,44000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (921234) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Weakly Positive 
• Salmonella (NCI)  (N-9247) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (215133) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive