National Toxicology Program

CASRN: 78-87-5

Formula: C3-H6-CL2

Synonyms/Common Names:

• PROPYLENE DICHLORIDE

Known Uses:

INTERMEDIATE; IN FINISHES, DRY CLEANING FLUIDS, AND PAINT REMOVERS; FUMIGANT, INSECTICIDE FOR STORED GRAINS, FRUITS, SOLVENT IN PLASTICS, IN ANTIKNOCK CMPDS (HSDB 1990)

Short-Term Toxicity

• 14-Day (Gavage)  (C55141) Completed 
  • NTIS No. PB87-114443  (Peer Review 06/29/1983)
    Citation: Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CAS No. 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C55141) Completed 
  • NTIS No. PB87-114443  (Peer Review 06/29/1983)
    Citation: Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CAS No. 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,60,1000, M: 0,30,500 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C55141) Report Complete 
  • TR-263 (NTIS No. PB87-114443)  (Peer Review 06/29/1983)
    Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CAS No. 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice Some Evidence 
  • Dose: FR&M: 0,125,250, MR: 0,62,125 MG/KG/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (568899) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (903632) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (800926) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (552580) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Positive 
• Mouse Lymphoma  (999130) Completed 
  •  Positive 
• Salmonella  (566847) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Weakly Positive 
• Salmonella  (627177) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Weakly Positive 
• Sister Chromatid Exchanges  (568899) Completed 
  • Mice
  • Sister Chromatid  Negative