National Toxicology Program

CASRN: 96-48-0

Formula: C4-H6-O2

Synonyms/Common Names:

• 2(3H)-FURANONE, DIHYDRO- (8CI)(9CI)

Known Uses:

INTERMEDIATE IN THE SYNTHESIS OF POLYVINYLPYRROLIDONE, DL-METHIONINE, PIPERIDINE, PHENYLBUTYRIC ACID, AND THIOBUTYRIC ACIDS. SOLVENT FOR RESINS. CONSTITUENT OF PAINT REMOVERS. TEXTILE AIDS. DRILLING OILS. (TDB)

Short-Term Toxicity

• 2-WEEK (Gavage)  (C55878) Completed 
  • NTIS No. PB92-189323  (Peer Review 07/09/1991)
    Citation: Toxicology and Carcinogenesis Studies ofg-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 75, 150, 300, 600, OR 1,200 MG/KG M: 0, 87, 175, 350, 700, OR 1,400 MG/KG ; 5/SEX/SPECIES
• 13-WEEK (Gavage)  (C55878) Completed 
  • NTIS No. PB92-189323  (Peer Review 07/09/1991)
    Citation: Toxicology and Carcinogenesis Studies ofg-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 56, 112, 225, 450 OR 900 MG/KG M: 0, 65, 131, 262, 525, OR 1,050 MG/KG; 10/SEX/SPECIES

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C55878) Report Complete 
  • TR-406 (NTIS No. PB92-189323)  (Peer Review 07/09/1991)
    Toxicology and Carcinogenesis Studies ofg-Butyrolactone (CAS No. 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Equivocal Evidence 
  • Female Mice No Evidence 
  • Dose: MR: 0, 112, OR 225 MG/KG FR: 0, 225, OR 450 MG/KG M: 0, 262, OR 525 MG/KG; 50/SEX/SPECIES

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (516280) Completed 
  • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (550692) Completed 
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (896754) Completed 
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella  (910246) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative