National Toxicology Program

CASRN: 100-52-7

Formula: C7-H6-O

Synonyms/Common Names:

• BENZOIC ALDEHYDE

Known Uses:

CHEMICAL INTERMEDIATE FOR DYES. SOLVENT FOR OILS, RESINS, SOME CELLULOSE ETHERS, CELLULOSE ACETATE AND NITRATE, FLAVORING COMPOUNDS, SYNTHETIC PERFUMES. (TDB)

Short-Term Toxicity

• 2-WEEK (Gavage)  (C56133) Completed 
  • NTIS No. PB90-253782  (Peer Review 06/27/1989)
    Citation: Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 100, 200, 400, 800, OR 1600 MG/KG M: O, 200, 400, 800, 1600, OR 3200 MG/KG; 5/SEX/SPECIES
• 13-WEEK (Gavage)  (C56133) Completed 
  • NTIS No. PB90-253782  (Peer Review 06/27/1989)
    Citation: Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 50, 100, 200, 400, OR 800 MG/KG M: 0, 75, 150, 300, 600, OR 1200 MG/KG; 10/SEX/SPECIES

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C56133) Report Complete 
  • TR-378 (NTIS No. PB90-253782)  (Peer Review 06/27/1989)
    Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Some Evidence 
  • Female Mice Some Evidence 
  • Dose: R&MM: 0, 200, OR 400 MG/KG FM: 0, 300, OR 600 MG/KG; 50/SEX/SPECIES

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (081912) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (143943) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (895369) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  •  Positive 
• Salmonella  (489344) Completed 
  •  Negative 
• Salmonella  (930477) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative