National Toxicology Program

CASRN: 25013-15-4

Formula: C9 H1O

Synonyms/Common Names:

• ETHENYLMETHYLBENZENE (9CI)

Known Uses:

PREPARING POLYESTER RESINS, MODIFIED ALKYL RESINS, AND DRYING OILS. IN ORTHOPEDIC CAST MATERIAL.

Short-Term Toxicity

• 14-Day (Inhalation)  (C56406) Completed 
  • NTIS No. PB90-260035  (Peer Review 11/20/1989)
    Citation: Toxicology and Carcinogenesis Studies of Vinyl Toluene (Mixed Isomers) (65%meta-isomer and 32-35 para-isomer) (CAS No. 25013-15-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Inhalation)  (C56406) Completed 
  • NTIS No. PB90-260035  (Peer Review 11/20/1989)
    Citation: Toxicology and Carcinogenesis Studies of Vinyl Toluene (Mixed Isomers) (65%meta-isomer and 32-35 para-isomer) (CAS No. 25013-15-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,25,1000, M: 0,10,160 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C56406) Report Complete 
  • TR-375 (NTIS No. PB90-260035)  (Peer Review 11/20/1989)
    Toxicology and Carcinogenesis Studies of Vinyl Toluene (Mixed Isomers) (65%meta-isomer and 32-35 para-isomer) (CAS No. 25013-15-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,100,300, M: 0,10,25 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (390795) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (327329) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (527349) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 

Organ Systems Toxicity

• 5 CONS D Dominant Lethal (Intraperitoneal Injection)  (T0141) Completed 
  • M Rats: Sprague Dawley
  • Dose: 500 MG/KF FOR 5 CONS D