National Toxicology Program

CASRN: 298-81-7

Formula: C12-H8-O4

Synonyms/Common Names:

• 9-METHOXY-7H-FURO(3,2-G)(1)(BENZOPYRAN-7-ONE) (9CI)
• 8-MOP

Known Uses:

USED IN PUVA THERAPY FOR TREATMENT OF PSORIASIS & VITILIGO, IN TANNING PREP'NS (PRIMARILY PROD. IN EUROPE)

Short-Term Toxicity

• 14-Day (Gavage)  (C55903) Completed 
  • NTIS No. PB90-110164  (Peer Review 04/18/1988)
    Citation: Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
• 13-Week (Gavage)  (C55903) Completed 
  • NTIS No. PB90-110164  (Peer Review 04/18/1988)
    Citation: Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
  • Dose: 0,25,400 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C55903) Report Complete 
  • TR-359 (NTIS No. PB90-110164)  (Peer Review 04/18/1988)
    Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats No Evidence 
  • Dose: R: 0, 37.5, 75 MG/KG/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (501444) Completed 
  • Mice
  • Chromosome Aberation  Positive 
• In Vitro Cytogenetics (CA/SCE)  (421568) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Micronucleus  (158726) Completed 
  • Mice: B6C3F1
  • Male Equivocal 
• Salmonella  (773087) Completed 
  •  Positive 

Organ Systems Toxicity

• GD 6 THROUGH 9 Conventional Teratology (Gavage)  (TER91016) Completed 
  • NTIS No. PB94-181731
    Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in New Zealand White Rabbits
  • NTIS No. PB94-191749
    Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in New Zealand White Rabbits
  • F Rabbit: New Zealand White
  • Rabbits Maternal Positive 
  • Rabbits Fetal Negative 
  • Dose: 0, 40, 80, 105 MG/KG
• GD 6-16 Conventional Teratology (Gavage)  (TER91017) Completed 
  • NTIS No. PB92-219666
    Citation: Final Report on the Developmental Toxicity of 8-Methoxypsoralen in Sprague-Dawley (CD) Rats
  • Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 0, 20, 80, 120, 160 MG/KG/DAY
• GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP90007) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 20, 100, 200, 400, 600 MG/KG
• GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP90008) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0, 10, 50, 80, 160 MG/KG
• GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP91017) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0, 10, 50, 80, 105 MG/KG