Summaries & Associations of Study Results
Levels from TR-530 TEF Evaluation (Binary Mixture; PCB 126/PCB 153)
Target Organs and Levels of Evidence
NTP Technical Report Number 530
Produced from Chemtrack Database 02/07/06
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) TEFBINARYMIX |
12/09/04 | ONE OF 2 MIXTURES BEING TESTED ALONG WITH 5 DIOXIN-LIKE COMPOUNDS TO DETERMINE IF THE TOXIC EQUIVALENCY FACTORS (TEFS) FOR THESE CHEMICALS WOULD BE PREDICTIVE OF RODENT CARCINOGENICITY. THIS MIXTURE CONSISTS OF TCDD, PENTACHLORODIBENZO-P-DIOXIN, PEN | Gavage FEMALE RATS ONLY: 0; (PCB126) 10, 100, 300, OR 1000 NG/KG; (PCB 153) 10, 100, 300, OR 1000 UG/KG; 50/DOSE | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| FR (CONSTANT RATIO MIXTURES): | ||||
| CLEAR EVIDENCE | LIVER: CHOLANGIOCARCINOMA 0/53 0/53 1/52 9/52 30/51 HEPATOCHOLANGIOMA 0/53 0/53 0/52 2/52 6/51 ADENOMA 0/53 0/53 3/52 5/52 27/51 | |||
| LUNG: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/52 1/53 11/52 | ||||
| ORAL CAVITY: SQUAMOUS CELL CARCINOMA (GINGIVAL) 0/53 0/53 2/53 5/53 9/53 | ||||
| PANCREAS ACINAR CELL: ADENOMA 0/53 1/53 1/52 3/52 1/50 ADENOMA OR CARCINOMA 0/53 1/53 1/52 4 /52 2/50 | ||||
| MAY HAVE BEEN RELATED: | UTERUS: SQUAMOUS CELL CARCINOMA 1/53 1/53 1/53 4/53 0/53 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; PIGMENTATION; DIFFUSE FATTY CHANGE; FOCAL FATTY CHANGE; EOSINOPHILIC FOCUS; TOXIC HEPATOPATHY; BILE DUCT CYST; BILE DUCT HYPERPLASIA; NECROSIS; OVAL CELL HYPERPLASIA; PORTAL FIBROSIS; NODULAR HYPERPLASIA, CHOLANGIOFIBROSIS | |||
| LUNG: SQUAMOUS METAPLASIA; ALVEOLAR EPITHELIUM METAPLASIA; BRONCHIOLAR METAPLASIA | ||||
| ORAL CAVITY: GINGIVAL SQUAMOUS HYPERPLASIA | ||||
| PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ACINAR ATROPHY | ||||
| ADRENAL CORTEX: ATROPHY; HYPERPLASIA | ||||
| THYROID GLAND: FOLLICULAR CELL HYPERTROPHY | ||||
| THYMUS: ATROPHY | ||||
| KIDNEY: SEVERITY OF NEPHROPATHY; PIGMENTATION | ||||
| NASAL CAVITY: RESPIRATORY EPITHELIAL HYPERPLASIA; OLFACTORY EPITHELIAL METAPLASIA | ||||
| FORESTOMACH: SQUAMOUS HYPERPLASIA | ||||
| LYMPH NODE:(MANDIBULAR) ECTASIA | ||||
Web page last updated on October 25, 2007
