Summaries & Associations of Study Results
Levels from TR-535 4-Methylimidazole
Target Organs and Levels of Evidence
NTP Technical Report Number 535
Produced from Chemtrack Database 01/04/06
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 4-METHYLIMIDAZOLE 822-36-6 |
09/28/05 | HAS BEEN REPORTED AS ONE OF SEVERAL COMPOUNDS RESULTING FROM INTERACTION OF REDUCING SUGARS WITH AMMONIA; MAJOR PHARMACEUTICAL INTERMEDIATE; STARTING MATERIAL FOR DRUG USED FOR ULCER THERAPY & OTHER DRUGS, ANTISEPTIC AGENTS; PHOTO DEVEL SOLUN. | Dosed-Feed MR: 0, 625, 1250, OR 2500 PPM; FR: 0, 1250, 2500, OR 5000 PPM; M: 0, 312, 625, OR 1250 PPM; 50/SEX/SPECIES/GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: HISTIOCYTOSIS; CHRONIC INFLAMMATION; HEPATOCYTIC FOCAL FATTY CHANGE; EOSINOPHILIC FOCUS; MIXED CELL FOCUS | |||
| FR: EQUIVOCAL EVIDENCE | MONONUCLEAR CELL LEUKEMIA: 9/50 7/50 16/50 20/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: HISTIOCYTOSIS; CHRONIC INFLAMMATION; HEPATOCYTIC FOCAL FATTY CHANGE; EOSINOPHILIC FOCUS; MIXED CELL FOCUS | |||
| MM: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 4/50 4/50 8/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA (COMBINED) 9/50 13/50 16/50 22/50 | |||
| FM: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 8/50 16/50 8/50 ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 0/50 2/50 7/50 COMBINED 3/50 8/50 17/50 14/50 | |||
| NON-NEOPLASTIC LESIONS: | LUNG: ALVEOLAR EPITHELIAL HYPERPLASIA | |||
Web page last updated on September 06, 2007
