Summaries & Associations of Study Results
TR-520 3,3',4,4',5-Pentachlorobiphenyl (PCB 126)
Target Organs and Levels of Evidence
NTP Technical Report Number 520
Produced from Chemtrack Database 05/14/04
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TOXIC EQUIVALENCY FACTOR EVALUATION ((PCB-126)3,3',4,4',5- PENTACHLOROBIPHENYL) 57465-28-8 |
02/17/04 | DIELECTRIC MEDIUM IN TRANSFORMERS | Gavage FEMALE RATS ONLY: PCB-126 -- 0, 10, 30, 100, 175, 300, 550, OR 1000 NG/KG; 100/DOSE | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| FR: CLEAR EVIDENCE | LIVER: CHOLANGIOCARCINOMA 0/53 0/55 1/53 0/53 5/53 6/51 22/53 2/50 OR ADENOMA 1/53 2/55 1/53 0/53 2/53 4/51 7/53 0/50 OR HEPATOCHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 0/51 3/53 0/50 | |||
| LUNG: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/55 0/53 0/53 1/53 11/51 35/51 0/50 OR SQUAMOUS CELL CARCINOMA 0/53 0/55 0/53 0/53 0/53 1/51 2/51 0/50 | ||||
| ORAL MUCOSA: GINGIVAL SQUAMOUS CELL CARINOMA 0/53 1/55 1/53 1/53 2/53 2/53 7/53 2/50 | ||||
| MAY HAVE BEEN RELATED: | ADRENAL CORTEX: ADENOMA OR CARCINOMA 0/52 2/55 1/53 0/53 1/53 1/52 4/53 3/50 | |||
| LIVER: CHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 1/51 1/53 0/50 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; BILE DUCT CYST; OVAL CELL HYPERPLASIA; NECROSIS; PIGMENTATION; INFLAMMATION; NODULAR HYPERPLASIA; PORTAL FIBROSIS; CHOLANGIOFIBROSIS; TOXIC HEPATOPATHY | |||
| LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA | ||||
| ADRENAL CORTEX: ATROPHY; CYTOPLASMIC VACUOLIZATION | ||||
| PANCREAS: CHRONIC ACTIVE INFLAMMATION; ACINAR ATROPHY; ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION | ||||
| KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY | ||||
| HEART: CARDIOMYOPATHY | ||||
| THYROID GLAND: FOLLICULAR CELL HYPERTROPHY | ||||
| THYMUS: ATROPHY; SEVERITY OF ATROPHY | ||||
| SPLEEN: LYMPHOID FOLLICULAR ATROPHY | ||||
| CLITORAL GLAND: CYSTIC DUCT | ||||
| MESENTERY: ARTERIAL CHRONIC ACTIVE INFLAMMATION | ||||
Web page last updated on February 10, 2006
