Summaries & Associations of Study Results
Levels from TR-515 Propylene Glycol Mono-t-butyl Ether
Target Organs and Levels of Evidence
NTP Technical Report Number 515
Produced from Chemtrack Database 02/07/06
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| PROPYLENE GLYCOL MONO-T-BUTYL ETHER 57018-52-7 |
05/22/03 | SOLVENT (USED AS A SUBSTITUTE SOLVENT FOR ETHYLENE GLYCOL MONO ALKYL ETHERS); USED IN ALL PURPOSE CLEANERS, COATINGS, INKS, NAIL POLISH, LACQUERS, LATEX PAINTS AND ADHESIVES. | Inhalation R&M: 0, 75, 300, OR 1200 PPM; 50/SEX/SPECIES/GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: EQUIVOCAL EVIDENCE | ||||
| MAY HAVE BEEN RELATED: | KIDNEY TUBULAR CELL: ADENOMA (STANDARD EVALUATION) 1/50 1/50 3/49 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 5/49 4/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 1/50 1/50 3/49 3/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 5/49 5/50 | |||
| LIVER: ADENOMA 3/50 0/50 2/49 6/50 | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: HYPERPLASIA; HYALINE DROPLET ACCUMULATION; PAPILLA MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY | |||
| LIVER: BASOPHILIC FOCI | ||||
| NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION | ||||
| FR: NO EVIDENCE | NONE | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | |||
| LIVER: CLEAR CELL FOCI | ||||
| NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION | ||||
| EYE: CORNEAL MINERALIZATION | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 18/50 23/49 26/50 36/50 CARCINOMA 9/50 8/49 13/50 11/50 COMBINED 25/50 26/49 33/50 41/50 HEPATOBLASTOMA 0/50 0/49 1/50 5/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: EOSINOPHILIC FOCI; MULTINUCLEATED HEPATOCYTES | |||
| FM: CLEAR EVIDENCE | LIVER: ADENOMA 14/49 8/50 10/50 37/49 CARCINOMA 4/49 8/50 7/50 10/49 COMBINED 18/49 14/50 16/50 41/49 HEPATOBLASTOMA 0/49 0/50 0/50 2/49 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: EOSINOPHILIC FOCI | |||
| EYE: CORNEAL MINERALIZATION | ||||
Web page last updated on February 10, 2006
