Summaries & Associations of Study Results
TR-493 Emodin
Target Organs and Levels of Evidence
NTP Technical Report Number 493
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
|
EMODIN
518-82-1 |
05/21/99 | MAJOR COMPONENT OF NATURAL LAXATIVE DRUGS OF PLANT ORIGIN. MEDICINE. NATURAL PLANT DYE. (2,3) | Dosed-Feed R: 0, 280, 830, OR 2500 PPM; 60/SEX M: 0, 160, 312, 625, OR 1250 PPM; 60/SEX | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
|
MR: NO EVIDENCE |
||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: TUBULAR CELL HYALINE DROPLET; TUBULAR CELL PIGMENTATION; INCREASED SEVERITY OF PIGMENTATION | |||
| OTHER CONSIDERATIONS: | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 28/50 31/50 29/50 18/50 | |||
|
FR: EQUIVOCAL EVIDENCE |
||||
| MAY HAVE BEEN RELATED: | ZYMBAL GLAND: CARCINOMA 0/50 0/50 0/50 3/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: TUBULAR CELL HYALINE DROPLET; INCREASED SEVERITY OF PIGMENTATION | |||
| OTHER CONSIDERATIONS: | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 17/50 16/50 3/50 | |||
|
MM: EQUIVOCAL EVIDENCE |
||||
| MAY HAVE BEEN RELATED: | KIDNEY TUBULAR CELL: ADENOMA (STANDARD) 0/49 1/50 1/50 0/50 (STANDARD AND EXTENDED) 0/49 1/50 1/50 1/50 OR CARCINOMA (STANDARD) 0/49 0/50 1/50 1/50 (STANDARD AND EXTENDED) 0/49 0/50 1/50 1/50 COMBINED (STANDARD) 0/49 1/50 2/50 1/50 (STANDARD AND EXTENDED) 0/49 1/50 2/50 2/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: TUBULAR CELL PIGMENTATION | |||
|
FM: NO EVIDENCE |
||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: TUBULAR CELL PIGMENTATION; INCERASED SEVERITY OF NEPHROPATHY | |||
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