Summaries & Associations of Study Results
TR-487 Isobutene
Target Organs and Levels of Evidence
NTP Technical Report Number 487
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| ISOBUTENE 115-11-7 |
12/10/97 | PROD'N OF DIISOBUTYLENE, TRIMERS, BUTYL RUBBER, ANTIOXIDANTS FOR FOODS, PACKAGING, FOOD SUPPLEMENTS & PLASTICS, ISOOCTANE, HIGH-OCTANE AVIATION GASOLINE. POLYISOBUTENE RESINS. (NTP EXECUTIVE SUMMARY) | Inhalation R&M: 0, 500, 2000, OR 8000 PPM (50/SEX/SPECIES/GROUP) | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | THYROID GLAND FOLLICULAR CELL: CARCINOMA 1/48 0/48 0/48 5/50 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: SEVERITY OF OLFACTORY EPITHELIAL HYALINE DEGENERATION | |||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: SEVERITY OF OLFACTORY EPITHELIAL HYALINE DEGENERATION | |||
| MM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION | |||
| FM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: EPITHELIAL HYALINE DEGENERATION | |||
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