Summaries & Associations of Study Results
TR-467 Chloroprene
Target Organs and Levels of Evidence
NTP Technical Report Number 467
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| CHLOROPRENE 126-99-8 |
12/11/96 | MONOMER FOR NEOPRENE ELASTOMERS. INDUSTRIAL RUBBER PRODUCTS. COMPONENT OF ADHESIVES IN FOOD PACKAGING. (TDB) | Inhalation R&M: 0, 12.8, 32.0, OR 80.0 PPM; 50/SEX/SPECIES/GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50 | |||
| THYROID GLAND FOLLICULAR CELL: ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 0/50 3/49 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/50 1/49 4/50 COMBINED 2/50 2/50 4/49 6/50 | ||||
| KIDNEY TUBULAR CELL: (SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50 | ||||
| MAY HAVE BEEN RELATED: | URINARY BLADDER: TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49 | |||
| NON-NEOPLASTIC LESIONS: | LUNG: ALVEOLAR EPITHELIUM HYPERPLASIA | |||
| KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | ||||
| NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; FIBROSIS; HYPERPLASIA; CHRONIC INFLAMMATION; METAPLASIA; NECROSIS | ||||
| FR: CLEAR EVIDENCE | ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50 | |||
| THYROID GLAND FOLLICULAR CELL: ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50 | ||||
| MAMMARY GLAND: FIBROADENOMA 24/49 32/50 36/50 36/50 | ||||
| KIDNEY TUBULAR CELL: (SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50 | ||||
| MAY HAVE BEEN RELATED: | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/49 0/50 0/50 3/50 | |||
| URINARY BLADDER: TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50 | ||||
| NON-NEOPLASTIC LESIONS: | LUNG: ALVEOLAR EPITHELIUM HYPERPLASIA | |||
| KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | ||||
| NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; FIBROSIS; HYPERPLASIA; CHRONIC INFLAMMATION; METAPLASIA, NECROSIS | ||||
| MM: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 8/50 18/50 22/50 28/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 12/50 23/50 28/50 COMBINED 13/50 28/50 36/50 43/50 | |||
| VASCULAR SYSTEM: HEMANGIOMA 0/50 1/50 2/50 2/50 OR HEMANGIOSARCOMA 3/50 13/50 22/50 19/50 COMBINED 3/50 14/50 23/50 21/50 | ||||
| HARDERIAN GLAND: ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50 | ||||
| KIDNEY TUBULAR CELL: (SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50 | ||||
| FORESTOMACH: SQUAMOUS CELL PAPILLOMA 1/50 0/50 2/50 4/50 | ||||
| NON-NEOPLASTIC LESIONS: | LUNG: BRONCHIOLE HYPERPLASIA; HISTIOCYTIC CELL INFILTRATION | |||
| FORESTOMACH: EPITHELIAL HYPERPLASIA | ||||
| KIDNEY: RENAL TUBULE HYPERPLASIA | ||||
| NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; METAPLASIA; HYPERPLASIA | ||||
| SPLEEN: HEMATOPOIETIC CELL PROLIFERATION | ||||
| FM: CLEAR EVIDENCE | LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 16/49 29/50 26/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 14/49 16/50 28/50 COMBINED 4/50 28/49 34/50 42/50 | |||
| VASCULAR SYSTEM: HEMANGIOMA 0/50 0/50 2/50 3/50 OR HEMANGIOSARCOMA 4/50 6/50 17/50 5/50 COMBINED 4/50 6/50 18/50 8/50 | ||||
| HARDERIAN GLAND: ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50 | ||||
| MAMMARY GLAND: CARCINOMA 3/50 4/50 7/50 12/50 | ||||
| LIVER: ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50 | ||||
| SUBCUTANEOUS TISSUE: SARCOMA 0/50 11/50 11/50 18/50 | ||||
| MESOTHELIUM (ABDOMINAL CAVITY/TUNICA VAGINALIS): SARCOMA 0/50 4/50 8/50 3/50 | ||||
| ZYMBAL GLAND: CARCINOMA 0/50 0/50 0/50 3/50 | ||||
| FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/50 0/50 0/50 4/50 | ||||
| NON-NEOPLASTIC LESIONS: | LUNG: BRONCHIOLE HYPERPLASIA; HISTIOCYTIC CELL INFILTRATION | |||
| FORESTOMACH: EPITHELIAL HYPERPLASIA | ||||
| NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; METAPLASIA; HYPERPLASIA | ||||
| SPLEEN: HEMATOPOIETIC CELL PROLIFERATION | ||||
Web page last updated on February 10, 2006
