Summaries & Associations of Study Results
TR-435 4,4-Thiobis(6-Tert-Butyl-m-Cresol)
Target Organs and Levels of Evidence
NTP Technical Report Number 435
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 4,4-THIOBIS(6-TERT-BUTYL-M- CRESOL) 96-69-5 |
06/22/93 | ANTIOXIDANT FOR SYNTHETIC & NATURAL RUBBER & LATEXES, STABILIZER FOR POLYETHYLENE FOOD PACKAGING (HSDB 1990). | Dosed-Feed R: 0,.05,.1,.25, M: 0,.025,.05,.1 % | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: KUPFFER CELL HYPERTROPHY; CYTOPLASMIC VACUOLIZATION; MIXED CELL FOCI | |||
| FR: NO EVIDENCE | ||||
| OTHER :CONSIDERATIONS: | MAMMARY GLAND: FIBROADENOMA, ADENOMA, OR CARCINOMA COMBINED 32/50 24/50 11/50 16/50 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: KUPFFER CELL HYPERTROPHY; CYTOPLASMIC VACUOLIZATION; FATTY CHANGE; MIXED CELL FOCI | |||
| KIDNEY: INCREASED SEVERITY OF NEPHROPATHY | ||||
| MM: NO EVIDENCE | ||||
| OTHER :CONSIDERATIONS: | LIVER: FATTY CHANGE 19/50 17/50 5/50 6/50; CLEAR CELL FOCI 6/50 5/50 2/50 0/50; ADENOMA OR CARCINOMA COMBINED 25/50 30/50 27/50 16/50 | |||
| FM: NO EVIDENCE | ||||
Web page last updated on February 10, 2006
