Summaries & Associations of Study Results
TR-416 o-Nitroanisole
Target Organs and Levels of Evidence
NTP Technical Report Number 416
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| O-NITROANISOLE 91-23-6 |
11/21/91 | USED AS AN INTERMEDIATE FOR THE PREPARATION OF O-ANISIDINE AND IN THE MANUFACTURE OF AZO DYES | Dosed-Feed (CORE STUDY) R: 0, 222, 666, 2000 PPM M: 0, 666, 2000, 6000 PPM (STOP STUDY) R: 0, 6000, 18000 PPM; 50/GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50 | |||
| URINARY BLADDER: (STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60 | ||||
| INTESTINES: (STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60 | ||||
| KIDNEY TRANSITIONAL CELL: PAPILLOMA (STOP STUDY) 0/60 0/60 4/60 OR CARCINOMA 0/60 1/60 8/60 | ||||
| MAY HAVE BEEN RELATED: | KIDNEY TUBULAR CELL: ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49 | |||
| FORESTOMACH: SQUAMOUS CELL PAPILLOMA O/50 0/50 1/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 1/50 | ||||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: FOCAL HYPERPLASIA; ULCERS | |||
| KIDNEY: TUBULAR FOCAL HYPERPLASIA; NEPHROPATHY; (STOP STUDY) TRANSITIONAL CELL HYPERPLASIA | ||||
| URINARY BLADDER: (STOP STUDY) TRANSITIONAL CELL HYPERPLASIA | ||||
| FR: CLEAR EVIDENCE | HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50 | |||
| URINARY BLADDER: (STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60 | ||||
| INTESTINES: (STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60 | ||||
| KIDNEY TRANSITIONAL CELL: (STOP STUDY) PAPILLOMA 0/60 0/60 1/60 OR CARCINOMA 0/60 0/60 1/60 | ||||
| MAY HAVE BEEN RELATED: | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/50 1/50 0/50 1/50 | |||
| NON-NEOPLASTIC LESIONS: | URINARY BLADDER: (STOP STUDY) TRANSITIONAL CELL HYPERPLASIA | |||
| FORESTOMACH: FOCAL HYPERPLASIA | ||||
| KIDNEY: (STOP STUDY) TRANSITIONAL CELL HYPERPLASIA | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50 | |||
| FM: SOME EVIDENCE | LIVER: ADENOMA 14/50 2/50 36/50 18/50 | |||
Web page last updated on February 10, 2006
