Summaries & Associations of Study Results
TR-405 C.I. Acid Red 114
Target Organs and Levels of Evidence
NTP Technical Report Number 405
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| C.I. ACID RED 114 6459-94-5 |
03/11/91 | DYE FOR SILK, JUTE FIBERS, WOOL, LEATHER. (TDB) | Dosed-Water MR: 0,70,150,300, FR: 0,150,300,600 PPM(70,45,75,70 PER GROUP RESPECTIVELY) | Hazleton (Vienna) |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | SKIN: BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50 | |||
| ZYMBAL GLAND: ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50 | ||||
| LIVER: NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50 | ||||
| MAY HAVE BEEN RELATED: | ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 0/50 0/35 1/65 2/50 | |||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 16/50 11/35 24/63 19/49 OR MALIGNANT PHEOCHROMOCYTOMA 2/50 0/35 3/63 2/49 COMBINED 17/50 11/35 27/63 21/49 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 2/35 1/65 3/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 2/50 2/35 2/65 3/50 | ||||
| FR: CLEAR EVIDENCE | SKIN: BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50 | |||
| ZYMBAL GLAND: ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50 | ||||
| CLITORAL GLAND: ADENOMA 7/48 10/32 10/62 10/50, CARCINOMA 4/48 9/32 19/62 15/50, COMBINED 11/48 17/32 28/62 23/50 | ||||
| LIVER: NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50 | ||||
| ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 0/50 3/35 6/65 4/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 3/65 2/50, COMBINED 0/50 3/35 9/65 6/50 | ||||
| INTESTINES: ADENOMATOUS POLYP 0/50 1/35 1/65 3/50, ADENOCARCINOMA 0/50 0/35 0/65 2/50, COMBINED 0/50 1/35 1/65 5/50 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50 | ||||
| MAY HAVE BEEN RELATED: | MAMMARY GLAND: ADENOCARCINOMA 0/50 3/35 6/65 3/50 | |||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 1/50 3/35 5/64 1/50 | ||||
| HEMATOPOIETIC SYSTEM: MONONUCLEAR CELL LEUKEMIA 12/50 13/35 18/65 5/50 | ||||
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