Summaries & Associations of Study Results
TR-351 P-Chloroaniline Hydrochloride
Target Organs and Levels of Evidence
NTP Technical Report Number 351
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| P-CHLOROANILINE HYDROCHLORIDE 20265-96-7 |
04/18/88 | AN AROMATIC AMINE WIDELY USED IN THE DYE, CHEMICAL, TEXTILE, RUBBER AND OTHER INDUSTRIES; AS AN INTERMEDIATE IN THE MANUFACTURE OF DYES AND PIGMENTS; DETECTED AS A DEGRADATION PRODUCT IN SOME PHARMACEUTICAL PREPARATIONS. | Gavage R: 0,2,6,18, M: 0,3,10,30 MG/KG/50 PER GROUP | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | SPLEEN: FIBROSARCOMA 0/49 1/50 2/50 17/50, HEMANGIOSARCOMA 0/49 0/50 0/50 4/50, OR OSTEOSARCOMA 0/49 0/50 1/50 19/50 COMBINED 0/49 1/50 3/50 38/50 | |||
| MAY HAVE BEEN RELATED: | ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 13/49 14/48 15/48 26/49 | |||
| NON-NEOPLASTIC LESIONS: | SPLEEN: FIBROSIS 3/49 11/50 12/50 41/50 | |||
| FR: EQUIVOCAL EVIDENCE | SPLEEN: FIBROSARCOMA 0/50 0/50 1/50 0/50 OR OSTEOSARCOMA 0/50 0/50 0/50 1/50 COMBINED 0/50 0/50 1/50 1/50 | |||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 2/50 3/50 1/50 6/50 | ||||
| MM: SOME EVIDENCE | VASCULAR SYSTEM (LIVER): HEMANGIOSARCOMA 2/50 2/50 1/49 6/50 | |||
| LIVER: ADENOMA 9/50 15/49 10/50 44/50 OR CARCINOMA 3/50 7/49 11/50 17/50 COMBINED 11/50 21/49 20/50 21/50 | ||||
| VASCULAR SYSTEM (SPLEEN): HEMANGIOSARCOMA 3/50 2/47 0/49 5/49 | ||||
| FM: NO EVIDENCE | ||||
Web page last updated on February 10, 2006
