Summaries & Associations of Study Results
TR-341 Nitrofurantoin
Target Organs and Levels of Evidence
NTP Technical Report Number 341
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| NITROFURANTOIN 67-20-9 |
04/18/88 | URINARY ANTIBACTERIAL AGENT. (TDB) | Dosed-Feed FR: 0,600,1300, MR&M: 0,1300,2500 PPM/50 PER GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 0/50 1/50 2/50 OR CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 3/50 | |||
| MAY HAVE BEEN RELATED: | BONE: OSTEOSARCOMA 0/50 1/50 2/50 | |||
| SUBCUTANEOUS TISSUE: FIBROMA 0/50 5/50 4/50; FIBROSARCOMA 1/50 2/50 1/50 | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: NEPHROPATHY, CHRONIC 50/50 48/50 48/50 | |||
| TESTES: DEGENERATION 0/50 0/50 36/50 | ||||
| FR: NO EVIDENCE | ||||
| MM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | TESTES: GERMINAL EPITHELIUM, DEGENERATION 0/49 3/49 23/50 | |||
| FM: CLEAR EVIDENCE | OVARY: TUBULAR CELL ADENOMA 0/50 0/50 5/50; BENIGN MIXED TUMORS 0/50 0/50 4/50; GRANULOSA CELL TUMOR 0/50 3/50 2/50 | |||
| NON-NEOPLASTIC LESIONS: | OVARY: ATROPHY 0/50 48/50 49/50 | |||
| ADRENAL GLAND: SPINDLE CELL, HYPERPLASIA 3/50 41/50 45/50 | ||||
Web page last updated on February 10, 2006
