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Reye Syndrome
1990 Case Definition
Clinical case definition
An illness that meets all of the following criteria:
- Acute, noninflammatory encephalopathy that
is documented clinically by a) an alteration in consciousness
and, if available, b) a record of the CSF containing less than
or equal to 8 leukocytes/cu.mm or a histologic specimen demonstrating
cerebral edema without perivascular or meningeal inflammation
- Hepatopathy documented by either a) a liver
biopsy or an autopsy considered to be diagnostic of Reye syndrome
or b) a threefold or greater increase in the levels of the
serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic
transaminase (SGPT), or serum ammonia
- No more reasonable explanation for the cerebral
and hepatic abnormalities
Case classification
Confirmed: a case
that meets the clinical case definition
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