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Plague (Yersinia pestis)
1990 Case Definition
Clinical description
A disease characterized by fever and leukocytosis
that presents in one or more of the following principal clinical
forms:
- Regional lymphadenitis (bubonic plague)
- Septicemia without an evident bubo (septicemic
plague)
- Plague pneumonia, resulting from hematogenous
spread in bubonic or septicemic cases (secondary plague pneumonia
) or inhalation of infectious droplets (primary plague pneumonia)
- Pharyngitis and cervical lymphadenitis resulting
from exposure to larger infectious droplets or ingestion of
infected tissues (pharyngeal plague)
- Plague is transmitted to humans by fleas or
by direct exposure to infected tissues or respiratory droplets.
Laboratory criteria for diagnosis
- Isolation of Yersinia pestis from
a clinical specimen, or
- Fourfold or greater change in serum antibody
to Y. pestis
Case classification
Probable: a clinically
compatible illness with supportive laboratory results (demonstration
of a single serologic test result suggestive of recent infection
with no history of immunization, or demonstration of a Fraction
I antigen in blood, bubo aspirate, or tissue by antigen detection
-- enzyme-linked immunosorbent assay (ELISA) or fluorescent assay
(FA))
Confirmed: a case that is laboratory confirmed
See also:
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