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Legionellosis (Legionella pneumophila) (Legionnaires’ Disease)
1995 Case Definition
The 1995 case definition appearing on this page was previously published in the 1990 MMWR
Recommendations and Reports titled Case Definitions for Public Health Surveillance
[MMWR 1990;39(RR13)] (available at
http://www.cdc.gov/mmwr/preview/mmwrhtml/00025629.htm).
Thus, the 1990 and 1995 versions of the case definition are identical.
Clinical description
An illness with acute onset, commonly characterized
by fever, cough, and pneumonia that is confirmed by chest radiograph.
Encephalopathy and diarrhea may also be included.
Laboratory criteria for diagnosis
- Isolation of Legionella from lung
tissue, respiratory secretions, pleural fluid, blood, or other
normally sterile sites, or
- Demonstration of a fourfold or greater rise
in the reciprocal immunofluorescence (IF) antibody titer to
greater than or equal to 128 against Legionella pneumophila serogroup
1, or
- Demonstration of L. pneumophila serogroup
1 in lung tissue, respiratory secretions, or pleural fluid
by direct fluorescence antibody testing, or
- Demonstration of L. pneumophila serogroup
1 antigens in urine by radioimmunoassay
Case classification
Probable: a clinically
compatible illness with demonstration of a reciprocal antibody
titer greater than or equal to 256 from a single convalescent-phase
serum specimen
Confirmed: a case that is laboratory confirmed
See also:
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