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Hepatitis C Virus Infection (past or present)

Contents
Home - National Notifiable Diseases Surveillance System
Overview
Introduction
List of Nationally Notifiable Diseases
Alphabetical List of Case Definitions
Definition of Terms
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2003 Case Definition

Clinical description

Most hepatitis C virus (HCV) infected persons are asymptomatic. However, many have chronic liver disease, which can range from mild to severe including cirrhosis and liver cancer.

Laboratory criteria for diagnosis

  • Anti-HCV positive (repeat reactive) by EIA, verified by an additional more specific assay (e.g. RIBA for anti-HCV or nucleic acid testing for HCV RNA), OR
  • HCV RIBA positive, OR
  • Nucleic acid test for HCV RNA positive, OR
  • Anti-HCV positive (repeat reactive) by EIA with a signal to cut-off ratio >= 3.8 (as this becomes available).

Case classification

Probable: a case that is anti-HCV positive (repeat reactive) by EIA and has alanine aminotranferase (ALT or SGPT) values above the upper limit of normal, but the anti-HCV EIA result has not been verified by an additional more specific assay or the signal to cutoff ratio is unknown.

Confirmed: a case that is laboratory confirmed and that does not meet the case definition for acute hepatitis C.

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This page last updated January 9, 2008

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