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Brucellosis (Brucella spp.)
1997 Case Definition
The 1997 case definition appearing on this page was previously published in the 1990 MMWR
Recommendations and Reports titled Case Definitions for Public Health Surveillance [MMWR 1990;39(RR13)]
(available at http://www.cdc.gov/mmwr/preview/mmwrhtml/00025629.htm).
Thus, the 1990 and 1997 versions of the case definition are identical.
Clinical description
An illness characterized by acute or insidious
onset of fever, night sweats, undue fatigue, anorexia, weight
loss, headache, and arthralgia
Laboratory criteria for diagnosis
- Isolation of Brucella spp. from a
clinical specimen, or
- Fourfold or greater rise in Brucella agglutination
titer between acute- and convalescent-phase serum specimens
obtained greater than or equal to 2 weeks apart and studied
at the same laboratory, or
- Demonstration by immunofluorescence of Brucella spp.
in a clinical specimen
Case classification
Probable: a clinically
compatible case that is epidemiologically linked to a confirmed
case or that has supportive serology (i.e., Brucella agglutination
titer of greater than or equal to 160 in one or more serum specimens
obtained after onset of symptoms)
Confirmed: a clinically compatible illness
that is laboratory confirmed
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