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F04B reviews fellowship applications covering structure and biophysical behavior and dynamics of biological macromolecules. This includes applications concerned with the structure-function relationships of proteins, nucleic acids, glycoproteins, lipid bilayers and membrane proteins; X-ray crystallography, multi-dimensional NMR, electron microscopy, circular dichroism, fluorescence, and computational methods; single molecule dynamics and interactions by fluorescence and microscopic techniques; and molecular interactions for defining and maintaining cellular shape and function. Examples of specific areas covered are listed below.
- Proteomics, global approaches to protein function, and posttranslational modification
- Computational data mining for analysis of proteins and related microarrays
- Physical chemistry of biological macromolecules, including conformation and structure of proteins and nucleic acids
- Spectroscopic methods, including multi-dimensional nuclear magnetic resonance, X-ray crystallography, Raman and FTIR
- Protein and nucleic acid folding and conformation by experimental and computational methods
- Thermodynamics of macromolecular interactions, including isothermal calorimetry
- Kinetic analyses, including pH or temperature jump methods
- Structure and physical chemistry of lipid bilayer membranes and related model systems
- Physical chemical instrumentation, including development of new approaches and application of computers to such instrumentation
- Indirect methods for structure and dynamics determinations, including fluorescence dye labeling and tethering
- Carbohydrate biochemistry and glycoproteins, including synthesis and processing
- Signal transduction at molecular or subcellular levels, including protein structure, function, and enzymology
- Extracellular matrix at molecular or subcellular levels
- Motility and cytoskeleton at molecular or subcellular levels
Shared Interests:
With F03A (Biochemical and Molecular Neuroscience): Fellowship applications concerned with neuronal function and structure in the areas of membrane recycling, protein structure-function and cytoskeleton structure may be assigned to F03A; fellowship applications concerned with quantitative analysis of biomolecular interactions and defining specific folding conformations may be assigned to F04B.
With F03B (Biophysical and Physiological Neuroscience): Fellowship; fellowship applications that focus on signal transduction and related processes that occur at the single cell neuronal level with emphasis on cell electrophysiology, molecular biophysics, and neurochemical pathways may be appropriate for F03B; fellowship applications concerned with quantitative analysis of biomolecular interactions and defining specific folding conformations may be assigned to F04B.
With F04A (Chemical and Bioanalytical Sciences) : Fellowship applications concerned with analysis of mechanism by inhibitor or kinetics studies related to the characterization of structure-function relationships of enzymes may be assigned to F04A; fellowship applications concerned with structure determination by X-ray crystallographic or NMR spectroscopic methods may be assigned to F04B.
With F05 (Cell Biology and Development) regarding cellular structure and function: Fellowship applications that are concerned with structural and functional studies of cells and cell components when the emphasis is on molecular and cell biological context may be assigned to F05; fellowship applications that are concerned with the molecular interactions among molecules that affect cellular structure may be assigned to F04B.
With F08 (Genomics, Genetics, DNA Replication, and Gene Expression): Fellowship applications focused on mechanisms of DNA replication/repair and gene expression/regulation may be assigned to F08; fellowship applications focused on enzymological or structural aspects of nucleic acids and nucleic acid protein interactions may be assigned to F04B. However, a biophysical study of DNA or RNA may be assigned to F04B, not F08.
With F09 (Oncological Sciences): Fellowship applications that are concerned with the physical chemistry and structure of proteins, lipids, and other biopolymers may be assigned to F04B; fellowship applications that are concerned with studying the properties of cancer specific proteins, lipids, and related compounds may be assigned to F09.
With F13 (Infectious Diseases and Microbiology): If the focus of the study is to elucidate the role of the molecule in infection, it may be assigned to F13. If the focus of an application is on studying chemistry or physics of a macromolecule without reference to its role in infection, assignment may be to F04B.
With F14 (Technology Development): Fellowship applications that are concerned with the development of new methods, instrumentation, or technology for use in studies of biological macromolecules may be assigned to F14; fellowship applications that are concerned primarily with elucidating the structural principles, biophysical behavior, and dynamics of biological macromolecules may be assigned to F04B. |