Stage2 tested compounds that inhibit the growth of the mlh1 mutant strain

The table below lists data for 64 compounds that inhibit the growth of the mlh1 mutant strain by at least 70% at the dose indicated.

Compounds that inhibited only the mlh1 mutant strain by at least 70% for at least one dose are at the top of the table.

Compounds that inhibit the mlh1 mutant strain PLUS several other strains by at least 70% are listed further down in the table. Caution: mlh1 is not necessarily the most sensitive strain when multiple strains are listed.

• Click on Stage2 Graphs to retrieve dose-response curves and a bar graph of the IC₅₀ values from which the IC₅₀ value of the appropriate wild type control has been subtracted.
• Click on 60 Cell Data to retrieve data (if available) from the 60 Human Tumor Cell Line Screen and to run COMPARE (an algorithm that finds compounds and molecular targets with similar patterns in the 60 cell screen). Not all compounds have been tested in the 60 cell line screen.
• To retrieve structural information (if any is available) click on 3D Structure.
• wt1 serves as the control for CLN2oe, bub3, mec2, rad14, rad18, rad50 & rad52.
• wt2 serves as the control for mgt1, mlh1, rad50EPP⁺ & sgs1.

Inhibited Strains

Email questions to: Susan Holbeck [holbecks@mail.nih.gov]