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Rare Diseases >> Abstract Details |
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Antimalarial Korupensamines And Pharmaceutical Compositions And Medical Uses Thereof |
Description of Invention:
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The class of compounds known as korupensamines exhibit in vitro and in vivo antimalarial activity and offer a potent new means for treating and controlling this devastating disease. As many as 2-3 million people worldwide die from malaria each year, and many more suffer from long-term chronic infection. The deadliest malarial parasites have become resistant to previously effective antimalarial drugs such as chloroquine and other clinically useful agents; therefore, effective new antimalarial drugs are urgently needed. These korupensamine compounds, which are isolated from a new species of the plant genus Ancistrocladus which is found in tropical Africa and southern and southeast Asia, effectively inhibit the growth, reproduction, and pathologic effects of a broad spectrum of Plasmodia parasites when given alone or in conjunction with previously available antimalarial agents. Licensees of this invention will be required to comport with all applicable federal and country-of-collection policies relating to biodiversity.
Michael R. Boyd (NCI) et al.
DHHS Reference No. E-096-1994/0 --
U.S. Patent 5,409,938 issued on 25 Apr 1995
Infectious Diseases
Infectious Diseases -Therapeutics-Anti-Parasitic Infectious Diseases -Therapeutics
For Additional Information Please Contact:
| RC Tang JD, LLM
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: 301/435-5031
Email: tangrc@mail.nih.gov
Fax: 301/402-0220
Web Ref: 158
Last Updated On: 10/98
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