Rare Diseases >> Abstract Details   Antimalarial Napthylisoquinoline Alkaloids And Pharmaceutical Compositions And Medicinal Uses Thereof Description of Invention: This invention provides new napthylisoquinoline alkaloid compounds, and compositions and methods of use of known and new napthylisoquinoline alkaloids, for treatment or prevention of malaria. Some compounds of this class occur naturally in plant species of the Ancistrocladaceae and Dioncophyllaceae plant families which are found in tropical Africa and southern and southeast Asia. The compounds exhibit effective antimalarial properties and offer important new weapons in the treatment of this devastating disease. The deadliest malarial parasites have become resistant to previously effective antimalarial drugs; therefore, effective new antimalarial drugs are urgently needed. These new naphthylisoquinoline compounds effectively inhibit the growth, reproduction, and pathologic effects of a broad spectrum of Plasmodia parasites, including drug-resistant strains. Inventors: Michael R. Boyd (NCI) et al. Patent Status: DHHS Reference No. E-090-1994/0 -- U.S. Patent 5,639,761 issued 17 Jun 1997 U.S. Patent 6,627,641 issued 30 Sep 2003 Portfolios: Infectious Diseases Infectious Diseases -Therapeutics-Anti-Parasitic Infectious Diseases -Therapeutics For Additional Information Please Contact: RC Tang JD, LLM NIH Office of Technology Transfer 6011 Executive Blvd, Suite 325 Rockville, MD 20852-3804 Phone: 301/435-5031 Email: tangrc@mail.nih.gov Fax: 301/402-0220 Web Ref: 157 Last Updated On: 10/98