Rare Diseases >> Abstract Details   Transmission-Blocking Vaccine Against Malaria (1) Description of Invention: A transmission blocking vaccine developed against malaria contains a recombinant virus, which encodes a unique portion of the sexual stage surface antigen of Plasmodium falciparum (referred to as Pfs25), or the Pfs25 protein purified from infected host cells. Mice inoculated with the recombinant virus developed antibodies capable of blocking transmission of the virus. None of the monoclonal antibodies known to block transmission recognize the reduced Pfs25 antigen. This vaccine, which induces high, long-lasting titers at low cost, can be useful for controlling malaria. Inventors: David C. Kaslow et al. (NIAID) Patent Status: DHHS Reference No. E-035-1991/0 -- U.S. Patent No. 6,780,417 issued 24 Aug 2004 Portfolios: Infectious Diseases Infectious Diseases -Vaccines-Parasitic Infectious Diseases -Vaccines For Additional Information Please Contact: Robert M. Joynes J.D. NIH Office of Technology Transfer 6011 Executive Blvd, Suite 325 Rockville, MD 20852-3804 Phone: (301)594-6565 Email: joynesr@mail.nih.gov Fax: (301) 402-0220 Web Ref: 1185 Last Updated On: 5/95