Rare Diseases >> Abstract Details   Attenuated Human Rotavirus Vaccine Description of Invention: Rotaviruses are recognized as the single most important etiologic agent of severe diarrhea in both developed and nondeveloped countries. This invention embodies an attenuated rotavirus as a vaccine. The claims of the invention relate to the generation of a cold-adapted virus that is not efficient in replication at normal human body temperatures and therefore may be capable of stimulating an immune response without causing illness. In a limited clinical trial, administration of a cold-adapted rotavirus vaccine to 26 adults demonstrated that the vaccine was safe, attenuated, and was capable of inducing a virus-specific serologic response. Inventors: Yasutaka Hoshino (NIAID) Albert Kapikian (NIAID) Robert Chanock (NIAID) Patent Status: DHHS Reference No. E-040-1994/2 -- U.S. Patent No. 7,150,984 issued 19 Dec 2006 Portfolios: Infectious Diseases Infectious Diseases -Vaccines-Viral-Non-AIDS (only) Infectious Diseases -Vaccines For Additional Information Please Contact: Kevin Chang Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd, Suite 325 Rockville, MD 20852-3804 Phone: 301/435-5018 Email: changke@mail.nih.gov Fax: 301/402-0220 Web Ref: 1192 Last Updated On: 2/96