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Runaway Train: Mutations in Dynactin’s Brake Cause Rare Syndrome
16 January 2009. Eight families with the rare neurodegenerative disorder Perry syndrome share mutations in the cellular transport protein dynactin...
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mGluR5 Antagonist Crosses First Human Testing Hurdle for Fragile X
16 January 2009. Fragile X mutations are the most common cause of inherited mental retardation, and often cause autistic symptoms and epilepsy...
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Seeing Red—Fluorescent Timers Trace Protein Trafficking
16 January 2009. It’s not all that surprising to see flashing blue lights in the red light district—unless you are talking cell biology...
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CAA Relief? Specialized Macrophages Help Flush Out Vascular Amyloid
16 January 2009. If Aβ clearance can be likened to housecleaning, scientists have found a new plumber...
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GO TO ALL RESEARCH NEWS  |
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In the spotlight
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Histone Deacetylases Provide Tailwind for Cell Cycle Hypothesis
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Make room, Aβ: HDACs, DNA repair, and gene regulation are here to stay. A spate of underwhelming recent clinical trial results has prompted quiet reappraisals of the amyloid hypothesis among some scientists in the Alzheimer field. At the same time, basic research is advancing other pathways that may participate in the causes underlying age-related neurodegeneration. MIT’s Li-Huei Tsai and Dohoon Kim will showcase one such pathway. They and others propose that p25/cdk5 induction by age-related stressors deregulates histone deacetylases. This would lift a physiological repression of cell cycle genes as a cost of enhancing DNA repair. And all this precedes actual neurodegeneration, the scientists say. Aβ plays a part in this scheme, but not the lead. Join Tsai, Kim, Bruce Yankner, Mark Mattson, Rachael Neve, and other thought leaders for a Live Webinar. Hear how HDACs and the cell cycle fit into the pathogenesis of Alzheimer’s, and join the debate.
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What's New
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Research Models: Tau - Posted 16 January 2009
We've added a new mouse model to our Research Models Tau directory: P301S tau (line PS19). |
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Research Models: Tau - Posted 16 January 2009
We've updated five Mapt EGFP mouse models: The Jackson Laboratory stock numbers 004779, 004808, 003741, 005491, and 007251. |
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Fan Mail - Posted 15 January 2009
We've added a new entry to our Fan Mail page from Uday Saxena. |
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Comments - Posted 15 January 2009
Read remarks by Rima Obeid, Wolfgang Herrmann about
Sontag J-M et al.
NEWS: Dietary Intake: New Results to Ponder on Vitamin A, Folate |
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Conferences - Posted 15 January 2009
Oxidative Stress & Disease: 8-13 March 2009, Il Ciocco Hotel and Resort, Lucca (Barga), Italy. |
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Comments - Posted 15 January 2009
Read remarks by Karl Herrup about Kim D et al.
PAPER: Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. |
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Conferences - Posted 15 January 2009
We've added a link to the program information for the 9th International Conference (AD/PD 2009). |
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Conferences - Posted 14 January 2009
Diabetes, Insulin & Alzheimer's Disease: 6 April 2009, To be announced, U.S.A. |
SEE MORE |
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