CounterACT Publications 2008

CounterACT Publications

Neurotoxic Organophosphorus Poisons (e.g. anti-convulsants, anti-seizures, neuroprotectants, cholinesterase reactivators, nerve agent bioscavengers)

Aroniadou-Anderjaska V, Fritsch B, Qashu F, and Braga MF. (2008) Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy. Epilepsy Res. 78(2-3): 102-16.  Abstract

Beck JM, Hadad CM. (2008) Hydrolysis of nerve agents by model nucleophiles: A computational study. Chem Biol Interact. 175(1-3): 200-3.  Abstract

Boado RJ, Zhang Y, Zhang Y, Wang Y, Pardridge WM. (2008) IgG-Paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier. Mol Pharm. [Epub ahead of print]  Abstract

Carter DS, Harrison AJ, Falenski KW, Blair RE, DeLorenzo RJ. (2008) Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Res. 79(2-3): 213-23.  Abstract

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, Delorenzo RJ. (2008) Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry. Eur J Pharmacol. 583(1): 77-83.  Abstract

Deshpande LS, Nagarkatti N, Sombati S, Delorenzo RJ. (2008) The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. Epilepsy Res 79(2-3): 158-65.  Abstract

Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, Delorenzo RJ. (2008) Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury. Neurosci Lett 441(1): 115-9.  Abstract

Ding SJ, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O. (2008) Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin. Chem Res Toxicol. 21(9): 1787-94.  Abstract 

Fawcett WP, Aracava Y, Adler M, Pereira EF, Albuquerque EX. (2008) Acute toxicity of organophosphorus compounds in guinea pigs is sex and age dependent and cannot be solely accounted by acetycholinesterase inhibition. J Pharmacol Exp Ther. [Epub ahead of print]  Abstract

Geyer BC, Woods RR, Mor TS. (2008) Increased organophosphate scavenging in a butyrylcholinesterase mutant. Chem Biol Interact 175(1-3): 376-9.  Abstract

Goodkin HP, Joshi S, Mtchedlishvili Z, Brar J, and Kapur J. (2008) Subunit-specific trafficking of GABAa receptors during status epilepticus. J Neurosci. 28(10): 2527-38.  Abstract  

Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Megarbane B, Maury E, Masson P, Lockridge O. (2008) Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum. J Appl Toxicol. [Epub ahead of print]  Abstract

Li H, Tong L, Schopfer LM, Masson P, Lockridge O. (2008) Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase. Chem Biol Interact 175(1-3): 68-72.  Abstract

Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P. (2008) Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including residue 59 lysines. J Biol Chem 283(33): 22582-90.  Abstract

Nagarkatti N, Deshpande LS, Delorenzo RJ. (2008) Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neurosci Lett. 436(3): 289-93.  Abstract

Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. (2008) Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chem Biol Interact. 175(1-3): 161-5.  Abstract

Reeves TE, Wales ME, Grimsley JK, Li P, Cerasoli DM, Wild JR. (2008) Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities. Protein Engineering, Design & Selection 21(6): 405-412. Abstract

Sun DA, Despande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, Delorenzo RJ. (2008) Traumatic brain injury causes a long-lasting calcium (Ca(2+))-plateau of elevated intracellular Ca levels and altered Ca(2+) homeostatic mechanisms in hippocamplal neurons surviving brain injury. Eur J Neurosci 27(7): 1659-72. Abstract

Talley TT, Harel M, Hibbs Re, Radic Z, Tomizawa M, Casida JE, Taylor P. (2008) Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci USA 105(21): 7606-11. Abstract

Tomizawa M, Maltby D, Talley TT, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. (2008) Atypical nicotinic agonist bound conformations conferring subtype selectivity. Proc Natl Acad Sci USA 105(5): 1728-32. Abstract

Wang H, Cheng X, Taylor P, McCammon JA, Sine SM. (2008) Control of cation permeation through the nicotinic receptor channel. PLoS Comput. Biol. 4(2): e41. Abstract

Wetherington J, Serrano G, Dingledine R. (2008) Astrocytes in the epileptic brain. Neuron 58(2): 168-78. Abstract

Woods RR, Geyer BC, Mor TS. (2008) Hairy-root organ cultures for the production of human acetylcholinesterase. BMC Biotechnol. 8(1): 95.  Abstract

Yeung DT, Smith JR, Sweeney, RE, Lenz DE, and Cerasoli DM. (2008). A gas chromatography-mass spectrometry approach to examine stereoselective interaction of human plasma proteins with soman. J. Anal. Toxicol. 32(1): 86-91. Abstract

 

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Vesicating Agents (e.g. sulfur mustard)

Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, Laskin JD. (2008) Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat. Toxicol Appl Pharmacol 231(3): 384-92.  Abstract

Black AT, Gray JP, Shakarjian MP, Mishin V, Laskin DL, Heck DE, Laskin JD. (2008) UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol 232(1): 14-24.  Abstract

Conlon P, Yang CJ, Wu Y, Chen Y, Martinez K, Kim Y, Stevens N, Marti AA, Jockusch S, Turro NJ, Tan W. (2008) Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc 130(1): 336-42.  Abstract

Day BJ. (2008) Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal. 10(2): 355-70.  Abstract

Day BJ. (2008) Catalase and glutathione peroxidase mimics. Biochem Pharmacol. [Epub ahead of print] Abstract

Gerecke DR, Chen M, Isukapalli SS, Gordon MK, Chang YC, Tong W, Androulakis IP, Georgopoulos PG. (2008) Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect. Toxicol Appl Pharmacol. [Epub ahead of print]  Abstract

Gould N, White CW, Day BJ. (2008) A role for mitochondrial oxidative stress in sulfur mustard analog CEES-induced lung cell injury and antioxidant protection.  J Pharmacol Exp Ther  [Epub ahead of print]  Abstract

Kim Y, Cao Z, Tan W. (2008) Molecular assembly for high-performance bivalent nucleic acid inhibitor. Proc Natl Acad Sci USA 105(15): 5664-9.  Abstract

Mallikaratchy P, Tang Z, Tan W. (2008) Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy. ChemMedChem 3(3): 425-8.  Abstract

Price JA, Rogers JV, McDougal JN, Shaw MQ, Reid FM, Kiser RC, Graham JS. (2008) Gene expression analysis of bromine-induced burns in porcine skin. Toxicol Lett 182(1-3): 69-78.  Abstract

O'Neill HC, Rancourt RC, White CW. (2008) Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH. Antioxidants & Redox Signaling 10(2): 277-85. Abstract

Shangguan D, Meng L, Cao ZC, Xiao Z, Fang X, Li Y, Cardonna D, Witek RP, Liu C, Tan W. (2008) Identification of liver cancer-specific aptamers using whole live cells. Anal Chem. 80(3): 721-8. Abstract

Svoboda KK, Fischman DA, Gordon MK. (2008) Embryonic chick corneal epithelium: A model system for exploring cell-matrix interactions. Dev Dyn. 237(10): 2667-75.  Abstract

Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R. (2008) Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES)-induced skin injury in SKH-1 hairless mice. Toxicol Sci. [Epub ahead of print]  Abstract

Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2008) Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med 44(6): 1169-79. Abstract

Xiao Z, Shangguan D, Cao Z, Fang X, Tan W. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14(6): 1769-75.  Abstract

 

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Pulmonary Agents (e.g. chlorine, bromine, etc.)

Bessac BF, Jordt SE. (2008) Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda).  23:360-70.  Abstract

Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest. 118(5): 1899-910. Abstract

Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE. (2008) Transient receptor potential ankyrin 1 antagonist block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J.  [Epub ahead of print]  Abstract

Che MM, Conti M, Boylan M, Sciuto AM, Gordon RK, Nambiar MP. (2008) Blood and bronchoalveolar lavage fluid acetylcholinesterase levels following microinstillation inhalation exposure to sarin in guinea pigs. Inhal Toxiocl. 20(9): 821-8.  Abstract

Chen L, Song W, Davis IC, Shrestha K, Schwiebert E, Sullender WM, Matalon S. (2008) Inhibition of Na+ transport in lung epithelial cells by respiratory syncytial virus infection. Am J Respir Cell Mol Biol. [Epub ahead of print]  Abstract

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. (2008) EGFR-tyrosine kinase inhibitors diminish transforming growth factor-alpha induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 294(6): L1217-25. Abstract

Janciauskiene S, Nita I, Subramaniyam D, Li Q, Lancaster JR, Matalon S. (2008) Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro. Am J Respir Cell Mol Biol. 39(6):631-7.  Abstract

Ji HL, Song W, Gao Z, Su XF, Nie HG, Jiang Y, Peng JB, He YX, Liao Y, Zhou YJ, Tousson A, Matalon S. (2008) SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms. Am J Physiol Lung Cell Mol Physiol. [Epub ahead of print]  Abstract

Leustik M, Doran S, Bracher A, Williams S, Squadrito GL, Schoeb TR, Postlethwait EM, Matalon S. (2008) Mitigation of chlorine induced lung injury by low molecular weight antioxidants. Am J Physiol Lung Cell Mol Physiol. 295(5): L733-43.  Abstract

Mongan M, Tan Z, Chen L, Peng Z, Dietsch M, Su B, Leikauf G, Xia Y. (2008) Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Toxicol Sci 104(2): 405-11. Abstract

Panayiotidis MI, Stabler SP, Allen RH, Papa A, White CW. (2008) Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutat Res [Epub ahead of print]  Abstract

Sartor MA, Leikauf GD, Medvedovic M. (2008) LRpath: A logistic regression approach for identifying enriched biological groups in gene expression data. Bioinformatics  [Epub ahead of print]  Abstract 

Tian X, Tao H, Brisolara J, Chen J, Rando RJ, Hoyle GW. (2008) Acute lung injury induced by chlorine inhalation in C57BL/6 and FVB/N mice. Inhal Toxicol. 20(9): 783-93. Abstract

 

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Metabolic/Cellular Toxins (e.g. cyanide)

Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. (2008) Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J. Infect. Dis. 197(3): 457-64. Abstract

 

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Paralytic Neurotoxins (e.g. scorpion toxins)

Cohen L, Lipstein N, Karbat I, Ilan N, Gilles N, Kahn R, Gordon D, Gurevitz M. (2008) Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated Na-channels. J. Biol. Chem. 283(22): 15169-76. Abstract

Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J. (2008) NMR analysis of interaction of Lqh-alphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel. Biochemistry 47(3): 911-21.  Abstract

Sokolov S, Kraus RL, Scheuer T, Catterall WA. (2008) Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II. Mol Pharmacol. 73(3): 1020-8.  Abstract

 

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Diagnostics (e.g. EEG devices, OP detectors/biosensors)

Lee A, Liu G, Heng C, Tan S, Lim T, Lin Y . (2008) Sensitive electrochemical detection of horseradish peroxidase at disposable screen-printed carbon electrode. Electroanalysis 20(18): 2040-6.  Abstract

Lin YY, Liu G, Wai CM, Lin Y. (2008) Bioelectrochemical immunoassay of polychlorinated biphenyl. Anal Chim Acta 612(1): 23-8. Abstract

Liu G, Wang J, Barry R, Petersen C, Timchalk C, Gassman PL, Lin Y. (2008) Nanoparticle-based electrochemical immunosensor for detection of phosphorylated acetylcholinesterase: An exposure biomarker of organophosphate pesticides and nerve agents. Chemistry - A European Journal 14(32): 9951-9.  Abstract

Wang H, Wang J, Timchalk C, Lin Y. (2008) Magnetic electrochemical immunoassays with quantum dot labels for sensitive detection of phosphorylated acetylcholinesterase in plasma.  Anal. Chem. 80(22): 8477-84.  Abstract

Wang J, Lin Y. (2008) Functionalized carbon nanotubes and nanofibers for biosensing applications. Trends Anal.Chem. 27(7): 619-26. Abstract  

Wang J, Liu G, Wu H, Lin Y. (2008) Quantum-dot-based electrochemical immunoassay for high-throughput screening of the prostate-specific antigen. Small 4(1): 82-6 Abstract

Wang J, Liu G, Timchalk C, Lin Y. (2008) Carbon nanotube-based electrochemical sensor for assay of salivary cholinesterase enzyme activity: an exposure biomarker of organophosphate pesticides and nerve agents. Environ. Sci. Technol. 42(7): 2688-2693. Abstract

Wu H, Huo Q, Varnum S, Wang J, Liu G, Nie Z, Liu J, Lin Y. (2008) Dye-doped silica nanoparticle labels/protein microarray for detection of protein biomarkers. Analyst 133: 1550-5. Abstract  

Wu H, Wang J, Wang Z, Fisher DR, Lin Y. (2008) Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapey of cancers. J Nanosci Nanotechnol. 8(5): 2316-22.  Abstract

 

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(66 Total 2008 Publications)