CounterACT Publications 2007

CounterACT Publications

Neurotoxic Organophosphorus Poisons (e.g. anti-convulsants, anti-seizures, neuroprotectants, nerve agent bioscavengers)

Deshpande LS, Limbrick DD Jr, Sombati S, and DeLorenzo, RJ. (2007) Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. J Pharmacol Exp Ther 322: 443-452. Abstract

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, and DeLorenzo RJ. (2007) In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons. Epilepsy Research 75(2-3): 171-179. Abstract

Evron T, Geyer BC, Cherni I, Muralidharan M, Kilbourne J, Fletcher SP, Soreq H, and Mor TS. (2007) Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath. FASEB J. 21:2961-9. Abstract

Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, and Redinbo MR. (2007) Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry, 46, 5063-5071. Abstract

Geyer BC, Fletcher SP, Griffin TA, Lopker MJ, Soreq H, Mor TS. (2007) Translational control of recombinant human acetylcholinesterase accumulation in plants. BMC Biotechnol. 7:27. Abstract

Harel M, Brumshtein B, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, and Sussman JL. (2007) 3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability. Arh Hig Rada Toksikol. 58(3):347-53. Abstract

Li B, Nachon F, Froment MT, Verdier L, Debouzy JC, Brasme B, Gillon E, Schopfer LM, Lockridge O, and Masson P. (2007) Binding and hydrolysis of soman by human serum albumin. Chem Res Toxicol. 21(2):421-31. Abstract

Li H, Schopfer LM, Masson P, and Lockridge O. (2007) Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers. Biochem J.411(2): 425-32.   Abstract

Martin BS and Kapur J. (2007) A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation. Epilepsia 49(2): 248-55. Abstract

Raza M, Deshpande LS, Blair RE, Carter DS, Sombati S, and DeLorenzo RJ. (2007) Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons. Neuroscience Letters 418 (1): 77-81. Abstract

Taylor P, Talley TT, Radic' Z, Hansen SB, Hibbs RE and Shi J. (2007) Structure-guided drug design: Conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes, Biochemical Pharmacology 74 (8): 1164-1171. Abstract

Tomizawa M, Maltby D, Medzihradszky KF, Zhang N, Durkin KA, Presley J, Talley TT, Taylor P, Burlingame AL, and Casida JE. (2007) Defining nicotinic agonist binding surfaces through photoaffinity labeling. Biochemistry 46: 8798-8806. Abstract

Tomizawa M, Talley TT, Maltby D, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. (2007) Mapping the elusive neonicotinoid binding site. Proc Natl Acad Sci USA 104(21): 9075-80. Abstract

 

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Vesicating Agents (e.g. sulfur mustard)

Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, and Laskin JD. (2007) Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes. Carcinogenesis 29(1): 219-25. Abstract

Chen LC, Gordon RE, Laskin JD, and Laskin DL. (2007) Role of TLR04 in liver macrophage and endothelial cell responsiveness during acute endotoxemia. Exp Mol Pathol. 83(3): 311-26. Abstract

Chen LC, Laskin JD, Gordon MK, and Laskin DL. (2007) Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Exp Mol Pathol. 84(2): 145-55. Abstract

Gray JP, Heck DE, Mishin V, Smith PJ, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, and Laskin JD. (2007) Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem. 282(11):7939-49. Abstract

Fakhrzadeh L, Laskin JD, and Laskin DL. (2007) Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis factor-alpha following ozone inhalation. Toxicol Appl Pharmacol 227(3): 380-9. Abstract  

Sunil VR, Laumbach RJ, Patel KJ, Turpin BJ, Lim HJ, Kipen HM, Laskin JD, and Laskin DL. (2007) Pulmonary effects of inhaled limonene ozone reaction products in elderly rats. Toxicol Appl Pharmacol. 222(2):211-20. Abstract

Sunil VR, Patel KJ, Nilsen-Hamilton M, Heck DE, Laskin JD, and Laskin DL. (2007) Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp Mol Pathol. 83(2):177-87. Abstract

 

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Pulmonary Agents (e.g. chlorine)

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, and Leikauf GD. (2007) Acrolein activated matrix metalloproteinase 9 contributes to persistent mucin production.  Am J Respir Cell Mol Biol. 38:446-454. Abstract

Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, and Leikauf GD. (2007) Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.  Am. J. Respir.Cell Mol. Biol. 37: 309-321. Abstract 

Song W, and Matalon S. (2007) Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates. Am J Physiol Lung Cell Mol Physiol 293: L855-L858. Abstract

Tichelaar JW, Wesselkamper SC, Chowdhury S, Yin H, Berclaz PY, Sartor MA, Leikauf GD, and Whitsett JA. (2007) Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression. Exp Lung Res. 33(8):385-417. Abstract

 

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Metabolic/Cellular Toxins (e.g. cyanide)

Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL Jr, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, and Boss GR. (2007) Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp. Biol. Med. (Maywood). 232(11): 1432-40. Abstract

Crankshaw DL, Goon DJ, Briggs JE, Delong D, Kuskowski M, Patterson SE, and Nagasawa HT. (2007) A novel paradigm for accessing efficacies of potential antidotes against neurotoxins in mice. Toxicol. Lett. 175(1-3): 111-7. Abstract

Nagasawa HT, Goon DJW, Crankshaw DL, Vince R, and Patterson SE. (2007) Novel, orally effective cyanide antidotes. J. Med. Chem. 50(26): 6462-4. Abstract

 

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Paralytic Neurotoxins (e.g. scorpion toxins)

Cohen L, Troub Y, Turkov M, Gilles N, Ilan N, Benveniste M, Gordon D, and Gurevitz M. (2007) Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned. Mol Pharmacol. 72(5):1220-7. Abstract

Cohen L, Ilan N, Gur M, Stuhmer W, Gordon D, Guervitz M. (2007) Design of a specific activator for skeletal muscle sodium channels uncovers channel architecture. J Biol Chem. 282(40):29424-30. Abstract

 

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Diagnostics (e.g. EEG devices, OP detectors/sensors)

Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O. (2007) Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411. Anal Biochem 361(2):263-72. Abstract

Li G and Lin Y. (2007) Nanomaterial labels in electrochemical immunosensors and immunoassays. Talanta 74(3):308-317. Abstract

Li H, Schopfer LM, Nachon F, Froment MT, Masson P, and Lockridge O. (2007) Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.  Toxicol. Sci. 100: 136-145. Abstract

Liu G, Lin Y, Wang J, Wu H, Wai CM, and Lin Y. (2007) Disposable electrochemical immunosensor diagnosis device based on nanoparticle probe and immunochromatographic strip. Anal. Chem. 79:7644-53 Abstract

Liu G, Wu H, Dohnalkova A, and Lin Y. (2007) Apoferrin-templated synthesis of encoded metallic phosphate nanoparticle tags. Anal. Chem. 79:5614-19. Abstract

Liu G, Wang J, Wu H, Lin Y, and Lin Y. (2007) Nanovehicles based bioassay labels. Electroanalysis 7-8:777-785. Abstract

Nagy JO, Zhang Y, Yi W, Liu X, Motari E, Song JC, Lejeune JT, Wang PG. (2007) Glycopolydiacetylene nanoparticles as a chromatic biosensor to detect Shiga-toxin producing Escherichia coli O157:H7. Bioorg. Med. Chem. Letters 18(2): 700-3. Abstract

Wang J, Liu G, Wu H, Lin Y. (2008) Quantum-dot-based electrochemical immunoassay for high-throughput screening of the prostate-specific antigen. Small 4(1): 82-6 Abstract

Wu H, Liu G, Wang J, and Lin Y (2007) Quantum-dots based electrochemical immunoassay of interleukin-1 alpha. Electrochemistry Communications 9:1573-77. Abstract

 

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(38 Total 2007 Publications)