The Registry of Toxic Effects of Chemical Substances
Asphalt |
UPDATE: February 2008 | MW: N/R | MF: N/R |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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DNA adduct
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skin | mouse
600 mg/kg
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CRNGDP 9,1253,1988
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DNA damage
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rat
other cell types
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641 µg/L
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MUREAV 557,137,2004
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micronucleus test
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rat
other cell types
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57.8 µg/L
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MUREAV 557,137,2004
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intramuscular | mouse
lowest published toxic dose: 12 gm/kg/12 week- intermittent
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Tumorigenic: Neoplastic by RTECS criteria | Tumorigenic: Tumors at site of application
ARPAAQ 70,372,1960
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intramuscular | rat
lowest published toxic dose: 5,400 mg/kg/24 week- intermittent
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Tumorigenic: Neoplastic by RTECS criteria | Tumorigenic: Facilitates action of known carcinogens
ARPAAQ 70,372,1960
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skin | mouse
lowest published toxic dose: 130 gm/kg/81 week- intermittent
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Tumorigenic: Carcinogenic by RTECS criteria | Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors
HYSAAV 33(4-6),180,1968
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skin | mouse
toxic dose : 69 gm/kg/43 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors
HYSAAV 33(4-6),180,1968
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skin | mouse
lowest published toxic dose: 905 gm/kg/2 year- intermittent
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Tumorigenic: Neoplastic by RTECS criteria | Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors
IMSUAI 34,255,1965
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
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inhalation | human
lowest published toxic dose: <10 mg/m3/5.5 year- intermittent
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Eye: Conjunctiva irritation | Lung, Thorax, or Respiration: Cough Gastrointestinal: Changes in structure or function of salivary glands
ARTODN 81,35,2007
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inhalation | human
lowest published toxic dose: 10 mg/m3/9 year- intermittent
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Lung, Thorax, or Respiration: Other changes | Gastrointestinal: Changes in structure or function of salivary glands Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
ARTODN 81,35,2007
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inhalation | mouse
lowest published toxic concentration: 35 mg/m3/10 day- intermittent
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Immunological Including Allergic: Decrease in humoral immune response
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TOXID9 60,27,2001
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inhalation | rat
lowest published toxic concentration: 100 mg/m3/6 hour/14 week- intermittent
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Olfaction: Tumors | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 135,S140,2002
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intratracheal | rat
lowest published toxic dose: 1.35 mg/kg/3 day- intermittent
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Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
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JJTHEC 65,1247,2002
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intratracheal | rat
lowest published toxic dose: 26.64 mg/kg/3 day- intermittent
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Blood: Changes in bone marrow not included in above
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JJTHEC 65,1247,2002
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REVIEWS:
ORGANIZATION
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STANDARD
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| REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 0.5 mg/m3 (inhalable)
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DTLVS* TLV/BEI,2007
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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Not classifiable as human carcinogen
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DTLVS* TLV/BEI,2007
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International Agency for Research on Cancer (IARC) Cancer Review
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Human Inadequate Evidence
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IMEMDT 35,39,1985
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International Agency for Research on Cancer (IARC) Cancer Review
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Group 3
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IMSUDL 7,133,1987
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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| REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
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PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
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FEREAC 54,7740,1989
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Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: Cancelled
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RBREV* -,101,1998
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Mine Safety and Health Administration (MSHA) STANDARD - air
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time-weighted average 5 mg/m3 (fume)
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DTLVS* 3,19,1971
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Occupational Exposure Limit - ARAB Republic of Egypt
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time-weighted average 5 mg/m3, JAN1993
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 5 mg/m3, JAN1993
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Occupational Exposure Limit - AUSTRIA
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TRK peak 10 mg/m3 (vapor and aerosol), JAN 2006
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Occupational Exposure Limit - BELGIUM
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time-weighted average 5 mg/m3, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 1 mg/m3, OCT 2002
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Occupational Exposure Limit - KOREA
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time-weighted average 5 mg/m3, 2006
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Occupational Exposure Limit - MEXICO
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time-weighted average 10 mg/m3, 2004
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 5 mg/m3, 2003
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Occupational Exposure Limit - NEW ZEALAND
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time-weighted average 5 mg/m3 (fume), JAN2002
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Occupational Exposure Limit - NORWAY
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time-weighted average 5 mg/m3, JAN1999
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Occupational Exposure Limit - POLAND
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time-weighted average 5 mg/m3 (fume), short term exposure limit 15 mg/m3 (fume), JAN1999
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 10 mg/m3, DEC2006
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 5 mg/m3; | short term exposure limit 10 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not classifiable as human carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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| REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ASPHALT FUMES-air
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Carcinogen ceiling concentration 5 mg/m3/15 minute
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NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 90320; | Number of Industries 175; Total Number of Facilities 38,326; Number of Occupations 111; Total Number of Employees Exposed 573,807
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 90320; |
Number of Industries 177; Total Number of Facilities 26,349; Number of Occupations 109; Total Number of Employees Exposed 471,039; Total Number of Female Employees Exposed 18,959 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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| REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used for making roads, roofs and for making tanks watertight
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NTP Carcinogenesis studies; selected, October 2000
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REFERENCES:
CODEN
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| REFERENCE
ARPAAQ
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Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher
information, see APLMAS.
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ARTODN
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Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep.
Ger.) V.32- 1974-
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CRNGDP
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Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford
OX8 1JJ, UK) V.1- 1980-
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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HYSAAV
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Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71.
Discontinued.
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IMEMDT
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IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
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IMSUAI
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Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher
information, see IOHSA5.
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IMSUDL
|
IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY
12210) No.1- 1979-
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JJTHEC
|
Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya,
Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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RBREV*
|
Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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