Suggested Background Reading

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The following is a collection of publications related to NTP testing. To obtain copies you may contact the journal cited or contact the National Library of Medicine PubMed.

Anderson MW, Hoel DG, Kaplan NL (1980). A General Scheme for the Incorporation of Pharmacokinetics in Low Dose Risk Estimation for Chemical Carcinogenesis. Example - Vinyl Chloride. Toxicol Appl Pharmacol. 55:154-161. (1)
Ashby J, Tennant RW (1988). Chemical Structure, Salmonella Mutagenicity and Extent of Carcinogenicity as Indicators of Genotoxic Carcinogenesis among 222 Chemicals tested in Rodents by the U.S. NCI/NTP. Mut Res. 204(1):17-115.(2)
Ashby J, Tennant RW (1991). Definitive Relationships Among Chemical Structure, Carcinogenicity and Mutagenicity for 301 Chemicals Tested by the U.S. NTP. Mut Res. 257(3):229-306.(3)
Bailer A, Portier C (1988). An Illustration of Dangers of Ignoring Survival Differences in Carcinogenic Data. J Appl Toxicol. 8(3):185-189.(4)
Bailer A, Portier C (1988). Effects of Treatment Induced Mortality and Tumor Induced Mortality on Tests for Carcinogenicity in Small Samples. Biometrics. 44(2):417-432.(5)
Barrett JC, Huff J (1991). Cellular and Molecular Mechanisms of Chemically Induced Renal Carcinogenesis. Renal Failure. 13(4): 211-225.(6)
Boorman GA, Montgomery CA, JR, Eustis SL, Wolfe MJ, McConnell EE, Hardisty JF (1985). Quality Assurance in Pathology for Rodent Carcinogenicity Studies. In: Handbook of Carcinogen Testing (H Milman, E Weisburger, Eds.), Noyes Publications, Park Ridge, NJ, pp. 345-357.(7)
Boorman GA, Banas DA, Eustis SL, Haseman JK (1987). Proliferative Exocrine Pancreatic Lesions in Rats. The Effect of Sample Size on the Incidence of Lesions. Toxicol Pathol. 15:451-456.(8)
Boorman GA, Haseman, Waters MD, Hardisty JF, Sills RC (2002). Quality Review Procedures Necessary for Rodent Pathology Databases and Toxicogenomic Studies: The National Toxicology Program Experience. Toxicol Path. 30(1):88-92. (117)
Bristol DW (1986). National Toxicology Program Approach to Monitoring Study Performance. In: Managing Conduct and Data Quality of Toxicology Studies, Princeton Scientific Publishing Co., Inc., pp. 79-97.(9)
Buchanan JR, Burka LT, Melnick RL (1997). Commentary: Purpose and guidelines for Toxicokinetic Studies within the National Toxicology Program. Environ Health Perspectives. Vol.105, No.5:468-471. (90)
Bucher JR, Portier CJ, Goodman JI, Faustman EM, Lucier GW (1996). National Toxicology Program Studies: Principles of Dose Selection and Applications to Mechanistic Based Risk Assessment. Editorial Material. Fundam Appl Toxicol. 31:1-8. (91)
Bucher JR (2000). Doses in Rodent Cancer Studies: Sorting Fact from Fiction. Drug Metabolism Reviews. 32(2), 153-163.(97)
Chapin RE, Sloane RA, Haseman JK (1998). Reproductive Endpoints in General Toxicity Studies: Are They Predictive? Reproductive Toxicology, Vol. 12, No.4, pp. 489-494. (94)
Chapin RE, Sloane RA (1996). Reproductive Assessment by Continuous Breeding: Evolving Study Design and Summaries of Eighty-Eight Studies. Environ Health Perspectives, Vol. 104, Supp.2, pp. 1-7. (128)
Chhabra RS, Huff JE, Schwetz BS, Selkirk J (1990). An Overview of Prechronic and Chronic Toxicity/Carcinogenicity Experimental Study Designs and Criteria Used by the National Toxicology Program. Environ Health Perspectives. 86:313-321.(10)
Dinse GE, Haseman JK (1986). Logistic Regression Analysis of Incidental Tumor Data from Animal Carcinogenicity Experiments. Fundam Appl Toxicol. 6:44-52.(11)
Dunnick JK, Elwell MR, Huff JE, Barrett JC (1995). Chemically Induced mammary gland cancer in the National Toxicology Program's carcinogenesis bioassay. Carcinogenesis 16:173-179.(12)
Dunson DB, Haseman JK, van Birgelen APJM, Stasiewicz S, Tennant RW (2000). Statistical Analysis of Skin Tumor Data from Tg.AC Mouse Bioassays. Toxicol Sciences. 55, 293-302. (106)
Eastin, WC (2005). Web Watch: National Toxicology Program's Updated Website - http://ntp.niehs.nih.gov. Toxicol Pathol. 33:800-801. (133)
Eastin, WC, Haseman, JK, Mahler, JF, and Bucher, JR (1998). The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens. Toxicol. Pathol. 26:461-473. (130)
Eastin, WC, Mennear, JH, Tennant, RW, Stoll, RE, Branstetter, DG, Bucher, JR, McCullough, B, Binder, RL, Spalding, JW, and Mahler, JF (2001). Tg.AC genetically altered mouse: Assay working group overview of available data. Toxicol. Pathol. 29 (suppl): 60-80. (131)
Fung VA, Huff J, Weisburger EK, Hoel DG (1993). Predictive Stragegies for Selecting 379 NCI/NTP Chemicals Evaluated for Carcinogenic Potential: Scientific and Public Health Impact. Fundam Appl Toxicol. 20:413-436.(13)
Fung VA, Barrett JC, Huff JE (1995). The carcinogenesis bioassay in perspective: application in identifying human cancer hazards. Environ Health Perspect 103:680-683. (14)
Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin BH, Resnick MA, Anderson B, and Zeiger E. (1987). Chromosome Aberrations and Sister Chromatid Exchanges in Chinese Hamster Ovary Cells: Evaluatons of 108 Chemicals. Environ. Molecular Mutagen. vol. 10 suppl. 10: 1-175. (107)
Haseman JK (1983). A Re-examination of False-Positive Rates for Carcinogenicity Studies. Fundam Appl Toxicol. 3:334-339.(15)
Haseman JK (1983). Patterns of Tumor Incidence in Two-Year Cancer Bioassay Feeding Studies in Fischer 344 Rats. Fundam Appl Toxicol. 3:1-9.(16)
Haseman JK, Huff JE, Boorman GA (1984). Use of Historical Control Data in Carcinogenicity in Rodents. Toxicol Pathol. 12(2):126-135. (17)
Haseman JK, Crawford DD, Huff JE, Boorman GA, McConnell EE (1984). Results from 86 Two-Year Carcinogenicity Studies Conducted by the National Toxicology Program. J Toxicol Environ Health. 14:621-639.(18)
Haseman JK (1984). Statistical Issues in the Design, Analysis and Interpretation of Animal Carcinogenicity Studies. Environ Health Perspect. 58:385-392.(19)
Haseman JK (1985). Issues in Carcinogenicity Testing: Dose Selection. Fundam Appl Toxicol. 5:66-78.(20)
Haseman JK, Huff JE, Rao GN, Arnold JE, Boorman GA, McConnell EE (1985). Neoplasms Observed in Untreated and Corn Oil Gavage Control Groups of F344/N Rats and (C57BL x C3H/HeN)F1 (B6C3F1) Mice. J Natl Cancer Inst. 75(5):975-984.(21)
Haseman JK, Winbush JS, O'Donnell MW (1986). Use of Dual Control Groups to Estimate False Positive Rates in Laboratory Animal Carcinogenicity Studies. Fundam Appl Toxicol. 7:573-584.(22)
Haseman JK, Tharrington EC, Huff JE, McConnell EE (1986). Comparison of Site-Specific and Overall Tumor Incidence Analyses for 81 Recent National Toxicology Program Carcinogenicity Studies. Regul Toxicol Pharmacol. 6:155-170.(23)
Haseman JK, Huff JE (1987). Species Correlation in Long-Term Carcinogenicity Studies. Cancer Lett. 37:125-132.(24)
Haseman JK, Huff JE, Zeiger E, McConnell EE (1987). Comparative Results of 327 Chemical Carcinogenicity Studies. Environ Health Perspect. 74:229-235.(25)
Haseman JK (1988). Lack of Cage Effects on Liver Tumor Incidence in B6C3F1 Mice. Fund Appl Toxicol. 10:179-187.(26)
Haseman JK (1988). Statistical Considerations in the Evaluation of Graded Responses in Carcinogenesis Studies. In: Carcinogenicity: The Design, Analysis, and Interpretation of Long-Term Animal Studies (ILSI Monograph), (H Grice and J Ciminera, Eds.), Springer-Verlag, New York, pp. 97-105.(27)
Haseman JK (1988). Do Cage Effects Influence Tumor Incidence? An Examination of Laboratory Animal Carcinogenicity Studies Utilizing Fischer 344 Rats. J Appl Toxicol. 8(4):267-276.(28)
Haseman JK, Huff JE, Rao GN, Eustis SL (1989). Sources of Variability in Rodent Carcinogenicity Studies. Fundam Appl Toxicol. 12:793-804.(29)
Haseman JK (1990). Use of Statistical Decision Rules for Evaluating Laboratory Animal Studies. Fundam Appl Toxicol. 14:637-648.(30)
Haseman JK (1992). Value of Historical Controls in the Interpretation of Rodent Tumor Data. Drug Info Jour. 26:191-200. (119)
Haseman JK, Rao GN (1992). Effects of Corn Oil, Time-Related Changes, and Inter-Laboratory Variability on Tumor Occurrence in Control of Fischer 344 (F344/N) Rats. Toxicol Pathol. 20(1):52-60. (124)
Haseman JK, Seilkop SK (1992). An Examination of the Association between Maximum-Tolerated Dose and Carcinogenicity in 326 Long-Term Studies in Rats and Mice. Fundam Appl Toxicol. 19:207-213. (126)
Haseman JK, Lockhart A (1993). Correlations between Chemically Related Site-specific Carcinogenic Effects in Long-Term Studies in Rats and Mice. Environ Health Perspect. 101(1):50-54.(113)
Haseman JK, Bourbina J, Eustis SL (1994). Effect of Individual Housing and Other Experimental Design Factors on Tumor Incidence in B6C3F1 Mice. Fundam Appl Toxicol. 23:44-52. (125)
Haseman JK, Lockhart A (1994). The Relationship between Use of the Maximum Tolerated Dose and Study Sensitivity for Detecting Rodent Carcinogenicity. Fundam Appl Toxicol. 22:382-391. (118)
Haseman JK, Piegorsch WW (1994). Statistical Analysis of Developmental Toxicity Data. Chapter 13: 349-361. In Developmental Toxicology Kimmell CA and Buelke-Sam J [eds.], Raven Press, New York. (115)
Haseman JK, Elwell MR (1996). Evaluation of False Positive and False Negative Outcomes in NTP Long-Term Rodent Carcinogenicity Studies. Risk Analysis. 16(6):813-820. (123)
Haseman JK, Johnson FM (1996). Analysis of National Toxicology Program rodent bioassay data for anticarcinogenic effects. Mutation Research. 350:131-141. (89)
Haseman JK, Boorman GA, Huff J (1997). Value of Historical Control Data and Other Issues Related to the Evaluation of Long-Term Rodent Carcinogenicity Studies. Toxicol Pathol. 25(5):524-527. (120)
Haseman JK, Hailey JR (1997). An update of the National Toxicology Program database on nasal carcinogens. Mut Res. 380:3-11.(114)
Haseman JK, Young E, Eustis SL, Hailey JR (1997). Body Weight--Tumor Incidence Correlations in Long-Term Rodent Carcinogenicity Studies. Toxicol Pathol. 25(3):256-263. (121)
Haseman JK (1998). National Toxicology Program Experience with Dietary Restriction: Does the Manner in which Reduced Body Weight is Achieved Affect Tumor Incidence? International Journal of Toxicology. 17(Suppl. 2):119-134, (116)
Haseman JK, Bailer AJ, Kodell RL, Morris RM, Portier K (2001). Forum: Statistical Issue in the Analysis of Low-Dose Endocrine Disruptor Data. Toxicol Sciences. 61:201-210. (122)
Haseman JK, Ney E, Nyska A, Rao, GN (2003). Effect of Diet and Animal Care/Housing Protocols on Body Weight, Survival, Tumor Incidences, and Nephropathy Severity of F344 Rats in Chronic Studies. Toxicol Pathol. 31:674-681. (112)
Hoel DG, Kaplan NL, Anderson MW (1983). Implication of Nonlinear Kinetics on Risk Estimation in Carcinogenesis. Science. 219:1032-1037. (31)
Hoel DG, Haseman JK, Hogan MD, Huff JE, McConnell EE (1988). The Impact of Toxicity on Carcinogenicity Studies: Implications for Risk Assessment. Carcinogenesis. 9(11):2045-2052.(32)
Huff JE (1982). Carcinogenesis Bioassay Results from the National Toxicology Program. Environ Health Perspect. 45:185-198. (33)
Huff JE, Moore JA (1984). Carcinogenesis Studies Design and Experimnetal Data Interpretation/Evaluation at the National Toxicology Program. In: Industrial Hazards of Plastics and Synthetic Elastomers (J Jarvisalo, P Pfaffli, H Vainio, Eds.), pp. 43-64.(34)
Huff JE, Haseman JK, McConnell EE, Moore JA (1986). The National Toxicology Program, Toxicology Data Evaluation Techniques, and Long-Term Carcinogenesis Studies. In: Safety Evaluation of Drugs and Chemicals (EE Lloyd, Ed.), Hemisphere Publishing Company, Washington, D.C., pp. 411-446.(35)
Huff JE, McConnell EE, Haseman JK, Boorman GA, Eustis SL, Schwetz BA, Rao GN, Jameson CW, Hart LG, Rall DP (1988). Carcinogenesis Studies: Results of 398 Experiments on 104 Chemicals from the U.S. National Toxicology Program. Ann NY Acad Sci. 534:1-30.(36)
Huff JE, Eustis SL, Haseman JK (1989). Occurrence and Relevance of Chemically Induced Benign Neoplasms in Long-term Carcinogenicity Studies. Cancer Metastasis Rev. 8:1-21.(37)
Huff J, Cirvello J, Haseman J, Bucher J (1991). Chemicals Associated with Site- Specific Neoplasia in 1394 Long-Term Carcinogenesis Experiments in Laboratory Rodents. Environ Health Perspect. Vol. 93, 247-270.(38)
Huff JE, Haseman JK (1991). Exposure to certain pesticides may pose real carcinogenic risk. C&EN. pp. 33-38.(39)
Huff J, Haseman J, Rall D (1991). Scientific Concepts, Value, and Significance of Chemical Carcinogenesis Studies. Ann Rev. Pharmacol Toxicol. 31:621-52.(40)
Huff J, Rall D (1991). Relevance to Humans of Carcinogenesis Results from Laboratory Animal Toxicology Studies. In: Maxdy-Rosenau's-Last Public Health and Preventive Medicine, 13th Edition (JM Last, RB Wallace, Eds.), Appleton Century Crofts, Norwalk, Connecticut, pp. 433-440, 453-457.(41)
Huff J, Haseman J (1991). Long-Term Chemical Carcinogenesis Experiments for identifying Potential Human Cancer Hazards: Collective Database of the National Cancer Institute and the National Toxicology Program (1976-1991). Environ Health Perspect. 96:23-31.(42)
Huff J, Hoel D (1992). Perspective and Overview of the Concepts and Value of Hazard Identification as the Intitial Phase of Risk Assessment for Cancer and Human Health. Presented at the course on Occupational Cancer and Carcinogenesis, Hanasaari Cultural Centre, Espoo, Finland, 12-16 November 1990. Scand. J. Work Environ. Health. 18 Suppl 1:83-9.(43)
Huff J (1992). A Historical Perspective on the Classification Developed and Used for Chemical Carcinogens by the National Toxicology Program, 1983 - 1992. Presented at the course on Occupational Cancer and Carcinogenesis, Hanasaari Cultural Centre, Espoo, Finland, 12-16 November 1990. Scand. J. Work Environ. Health. 18 Suppl 1:74-82.(44)
Huff J (1992). Design Strategies, Results and Evaluations of Long-Term Chemical Carcinogenesis Studies. Presented at the course on Occupational Cancer and Carcinogenesis, Hanasaari Cultural Centre, Espoo, Finland, 12-16 November 1990. Scand. J. Work Environ. Health. 18 Suppl 1:31-7.(45)
Huff J (1993). Chemicals and Cancer in Humans: First Evidence in Experimental Animals. Environ Health Perspect. 100:201-210.(46)
Huff JE (1994). Chemicals causally associated with cancers in humans and in laboratory animals: A perfect concordance. Chapter 2: 25-37. In: Waalkes MP & Ward JM [eds]. Carcinogenesis. Raven Press, New York. (47)
Huff JE (1994). Chemically Associated Respiratory Carcinogenesis in Rodents and in Humans. Chapter 7: 199-214. In: Waalkes MP & Ward JM [eds]. Carcinogenesis. Raven Press, New York. (48)
Huff JE (1995). Mechanisms, chemical carcinogenesis, and risk assessment: cell proliferation and cancer. Amer J Indust Med 27:293-300.(49)
Jameson CW (1984). Analytical Chemistry Requirements for Toxicity Testing of Environmental Chemicals. In: Chemistry for Toxicity Testing (CW Jameson, DB Walters, Eds.), Butterworth Publishers, Boston, Mass., pp. 3-14.(50)
Kanno J, Onyon L, Haseman J, Fenner-Crisp P, Ashby J, Owens W (2001). The OECD Program to Validate the Rat Uterotrophic Bioassay to Screen Compounds for In Vivo Estrogenic Responses: Phase 1. Environ. Health Perspect. 109(8): 785-794. (102)
Kaplan N, Hoel D, Portier C, Hogan M (1988). An Evaluation of the Safety Factor Approach in Risk Assessment. In: Developmental Toxicology: Mechanisms and Risk (J. McLachlan, Ed.), Banbury Report 26, Cold Spring Harbor Laboratory, New York, pp. 335-346.(51)
Lamb JC (1985). Reproductive Toxicity Testing: Evaluating and Developing New Testing Systems. Journal of the American College of Toxicology. 4(2):163-171.(52)
Luijckx NBL, Rao GN, McConnell EE, Wurtzen G, Kroes R (1994). The Intake of Chemicals Related to Age in Long-Term Toxicity Studies--Considerations for Risk Assessment. Regulatory Toxicol and Pharmacol. 20:96-104.(53)
Luster MI, Blank JA, Dean JH (1987). Molecular and Cellular Basis of Chemically Induced Immunotoxicity. Ann Rev Pharmacol Toxicol. 27:23-49.(54)
Luster MI, Munson AE, Thomas PT, Holsapple MP, Fenters, JD, White KL Jr., Lauer LD, Germolec DR, Rosenthal GJ, Deans JH (1988). Methods Evaluation. Development of a Testing Battery to Assess Chemical-Induced Immunotoxicity: National Toxicology Program's Guidelines for Immunotoxicity Evaluation in Mice. Fundam Appl Toxicol. 10:2-19.(55)
Luster MI, Portier C, Pait DG, White KL Jr., Gennings C, Munson AE, Rosenthal GJ (1992). Risk Assessment in Immunotoxicology: I. Sensitivity and Predictability of Immune Tests. Fundam Appl Toxicol. 18:200-210. (109)
Luster MI, Portier C, Pait DG, Rosenthal GJ, Germolec DR, Corsini E, Blaylock BL, Pollock P, Kouchi Y, Craig W, White KL, Munson AE, Comment CE (1993). Risk Assessment in Immunotoxicology: II. Relationships between Immune and Host Resistance Tests. Fundam Appl Toxicol. 21:71-82. (110)
Maronpot RR, Montgomery CA, Boorman GA, McConnell EE (1986). National Toxicology Program Nomenclature for Hepatoproliferative Lesions of Rats. Toxicol Pathol. 14(2):263-275.(56)
Maronpot RR, Haseman JK, Boorman GA, Eustis SL, Rao GN, Huff JE (1987). Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position. Arch Toxicol. Suppl. 10:10-26.(57)
McConnell EE, Solleveld HA, Swenberg JA, Boorman GA (1986). Guidelines for Combining Neoplasms for Evaluation of Rodent Carcinogenesis Studies. J Natl Cancer Inst. 76(2):283-289.(58)
Melnick RL, Jameson CW, Goehl TJ, Kuhn GO (1987). Application of Microencapsulation for Toxicology Studies. I. Principles and Stabilization of Trichloroethylene in Gelatin-Sorbitol Microcapsules. Fundam Appl Toxicol. 8(4):425-431.(59)
Melnick RL, Jameson CW, Goehl TJ, Maronpot RR, Collins BJ, Greenwell A, Harrington FW, Wilson RE, Tomaszewski KE, Agrawal DK (1987). Application of Microencapsulation for Toxicology Studies. II. Toxicity of Microencapsulated Trichloroethylene in Fischer 344 Rats. Fundam Appl Toxicol. 8(4):432-442.(60)
Melnick RL & Huff JE (1994). Liver carcinogenesis is not a predicted outcome of chemically induced hepatocyte proliferation. Adv Mod Environ Toxicol 23: 513-537. In: Mehlman MA., Upton A [eds]. Identification & public health control of environmental & occupational diseases: hazards & risks of chemicals in the oil refining industry. Princeton Sci. Pub. Co. Princeton, NJ. 689 pp. [Reprinted:Toxicol Indust Health: 9:1-25, 1993].(61)
Melnick R, Lucier G, Wolfe M, Hall R, Stancel G, Prins G, Gallo M, Reuhl K, Ho S, Brown T, Moore J, Leakey J, Haseman J, and Kohn M (2002). Summary of the National Toxicology Program's Report of the Endocrine Distuptors Low Dose Peer Review (Workshop Summary). Environ. Health Perspect. 110(4): 427-431. (104)
Morgan DL, Dunnick JK, Goehl T, Jokinen MP, Matthews HB, Zeiger E, Mennear JH (1994). Summary of the National Toxicology Program Benzidine Dye Initiative. Environ. Health Perspect. 102(2): 63-78. (95)
Morrissey RE, Lamb JC IV, Schwetz BA, Teague JL, Morris RW (1988). Association of Sperm, Vaginal Cytology, and Reproductive Organ Weight Data with Results of Continuous Breeding Reproduction Studies in Swiss (CD-1) Mice. Fundam Appl Toxicol. 11: 359-371. (92)
Morrissey RE, Schwetz BA, Lamb JC IV, Ross MD, Teague JL, Morris RW (1988). Evaluation of Rodent Sperm, Vaginal Cytology, and Reproductive Organ Weight Data from National Toxicology Program 13-Week Studies. Fundam Appl Toxicol. 11: 343-358. (93)
Mortelmans K, Zeiger E (2000). The Ames Salmonella/microsome mutagenicity assay. Mutation Research. 455:29-60.(98)
Padila-Banks E, Jefferson WN, Newbold RR (2001). The Immature Mouse Is a Suitable Model for Detection of Estrogenicity in the Uterotropic Bioassay. Environ. Health Perspect. 109(9): 821-826. (101)
Portier CJ, Bailer AJ (1989). Testing for increased carcinogenicity using a survival-adjusted quantal response test. Funda. Appl. Toxicol. 12: 731-737.(108)
Portier C, Hoel D (1983). Optimal Design of the Chronic Animal Bioassay. J Toxicol Environ Health. 12:1-19.(62)
Portier C, Hoel D (1984). Design of Animal Carcinogenicity Studies for Goodness-of-fit of Multistage Models. Fundam Appl Toxicol. 4:949-959.(63)
Portier C, Hoel D (1987). Issues Concerning the Estimation of the TD50. Risk Analysis. 7:437-447.(64)
Portier C (1988). Life Table Analysis of Carcinogenicity Experiments. J Am Coll Toxicol. 7(5):575-582.(65)
Portier C (1991). Design of Two-Year Carcinogenicity Experiments: Dose Allocation, Animal Allocation and Sacrifice Times. In: Statistics in Toxicology (D Krewski and C Franklin, Eds.), Gordon & Breach Science Publishers, New York, pp. 457-469.(66)
Portier C (1988). Species Correlation of Chemical Carcinogens. Risk Analysis. 8(4):551-553.(67)
Rall DP, Hogan MD, Huff JE, Schwetz BA, Tennant RW (1987). Alternatives to Using Human Experience in Assessing Health. Ann Rev Public Health. 8:355-85.(68)
Rall DP (2000). Laboratory Animal Tests and Human Cancer. Drug Metabolism Reviews. 32(2), 119-128.(96)
Rao GN, Piegorsch WW, Haseman JK (1987). Influence of Body Weight on the Incidence of Spontaneous Tumors in Rats and Mice of Long-Term Studies. Am J Clin Nutr. 45:252-260.(69)
Rao GN, Morris RW, Seely JC (2001). Beneficial Effects of NTP-2000 Diet on Growth, Survival, and Kidney and Heart Disease of Fischer 344 Rats in Chronic Studies. Toxicol. Sci. 63:245-255. (103)
Rao GN, Hickman RL, Sielkop SK, Boorman GA (1987). Utero-Ovarian Infection in Aged B6C3F1 Mice. Lab Anim Sci. 37(2):153-158.(70)
Rao GN, Knapka JJ (1987). Contaminant and Nutrient Concentrations of Natural Ingredient Rat and Mouse Diet Used in Chemical Toxicology Studies. Fundam Appl Toxicol. 9:329-338.(71)
Rao GN (1988). Rodent Diets For Carcinogenesis Studies. J Nutr. 118:929-931.(72)
Rao GN, Birnbaum LS, Collins JJ, Tennant RW, Skow LC (1988). Mouse Strains for Chemical Carcinogenicity Studies: Overview of Workshop. Fundam Appl Toxicol. 10(3):385-394.(73)
Rao GN (1997). New Nonpurified Diet (NTP-2000) for Rodents in the National Toxicology Program Toxicology and Carcinogenicity Studies. Presented at the symposium "Animal Diets for Nutritional and Toxicological Research" sponsored by the American Society for Nutritional Sciences April 15, 1996. 842S-846S. (88)
Reynolds SH, Stowers SJ, Patterson RM, Maronpot, RR, Aaronson SA, Anderson MW (1987). Activated Oncogenes in B6C3F1 Mouse Liver Tumors: Implications For Risk Assessment. Science. 237:1309-1316.(74)
Schwetz BA, Harris MW (1993). Developmental Toxicology: Status of the Field and Contribution of the National Toxicology Program. Environ Health Perspect. 100:269-282. (105)
Selkirk JK, Soward SM (compiled and edited by) (1993). Compendium of Abstracts from Long-Term Cancer Studies Reported by the National Toxicology Program of the National Institute of Environmental Health Sciences from 1976 to 1982 (includes up-to-date addendum). Environ Health Perspect. Supplements 101(1):295 pp.(99)
Shelby MD, Stasiewicz S (1984). Chemicals Showing no Evidence of Carcinogenicity in Long-Term, Two-Species Rodent Studies: The Need for Short-Term Test Data. Environ Mutagen. 7:871-878.(75)
Shelby MD (1988). The Genetic Toxicity of Human Carcinogens and its Implications. Mut Res. 204(1):3-15.(76)
Shelby MD, Zeiger E (1990). Activity of human carcinogens in the Salmonella and rodent bone-marrow cytogenetics tests. Mutation Research. 234:257-261. (84)
Shelby MD, et al. (1993). Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ. Molec. Mutagen. 21:160-179. (85)
Shelby MD, Witt K (1995). Comparison of results from mouse bone marrow chromosome aberrations and micronucleus tests. Environ. Molec. Mutagen. 25:301-313. (86)
Solleveld HA, Haseman JK, McConnell EE (1984). The Natural History of Body Weight Gain, Survival and Neoplasia in the Fischer 344 Rat. J Natl Cancer Inst. 72:929-940.(77)
Stokes WS (2002). Humane Endpoints for Laboratory Animals Used in Regulatory Testing. ILAR Journal. Volume 43, Supplement:S31-S38. (111)
Stowers SJ, Maronpot RR, Reynolds SH, Anderson MW (1987). The Role of Oncogenes in Chemical Carcinogenesis. Environ Health Perspect. 75:81-86.(78)
Tennant RW (1993). Stratification of Rodent Carcinogenicity Bioassay Results to Reflect Relative Human Hazard. Mut Res. 286:111-118.(81)
Tennant RW, Margolin BH, Shelby MD, Zeiger E, Haseman JK, Spalding J, Caspary W, Resnick M, Stasiewicz S, Anderson B, Minor R (1987). Prediction of Chemical Carcinogenicity in Rodents from in vitro Genetic Toxicity Assays. Science. 236:933-941.(79)
Tennant RW, Ashby J (1991). Classification According to Chemical Structure, Mutagenicity to Salmonella and Level of Carcinogenicity of a further 39 Chemicals Tested for Carcinogenicity by the U.S. National Toxicology Program. Mut Res. 257(3):209-227.(80)
Tennant, RW, Stasiewicz, S, Eastin, WC, Mennear, JH, and Spalding, JW (2001). The Tg.AC (v-Ha-ras) transgenic mouse: Nature of the model. Toxicol. Pathol. 29 (suppl):51-59. (132)
Thompson MB (1992). Clinical Pathology in the National Toxicology Program. Toxicol Pathol. 20(3/Part 2):484-489.(129)
Tilson H (1990). Animal Neurobehavioral Test Battery in NTP Assessment. In: Advances in Neurobehavioral Toxicology: Applications in Environmental and Occupational Health (Barry L. Johnson, Ed.), Lewis Publishers, Inc.. pp. 403-418.(82)
Travlos GS, Morris RW, Elwell MR, Duke A, Rosenblum S, Thompson MB (1996). Frequency and relationships of clinical chemistry and liver and kidney histopathology findings in 13-week toxicity studies in rats. Toxicology 107:17-29. (87)
Turusov VS, Mikinori T, Sills RC, Willson GA, Herbert RA, Hailey JR, Haseman JK, Boorman GA (2002). Lab Animal & Molecular Pathology: Hepatoblastomas in Mice in the US National Toxicology Program (NTP) Studies. Toxicol Pathol. 30(5):580-591. (127)
Zeiger E, Haseman JK, Shelby MD, Margolin BH, Tennant RW (1990). Evaluation of Four In Vitro Toxicity Tests for Predicting Rodent Carcinogenicity: Confirmation of Earlier Results with 41 Additional Chemicals. Environ & Molec Mut 16(18): 1-14. (83)

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Web page last updated on June 16, 2006