Mission Statement:
- Understanding the cellular, molecular and genetic basis of alcohol-induced liver disease, including the role of alcohol in hepatic carcinogenesis;
- research on cytokines and their signaling pathways as targets for the actions of ethanol in the liver.
Staff:
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Selected Publications:
Radaeva S, Jaruga B, Hong F, Kim WH, Fan S, Cai H, Strom S, Liu Y, El-Assal O, Gao B: Interferon-a activates multiple STAT signals and downregulates c-Met in primary human hepatocytes. Gastroenterology 2002;122:1020-34. 
Hong F, Jaruga B, Kim WH, Radaeva S, Tian Z, El-Assal O, Nguyen V, Gao B: Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest 2002;110(10):1503-13. [PDF]
Sun Z, Klein AS, Radaeva S, Hong F, El-Assal O, Jaruga B, Pan H, Batkai S, Tian Z, Hoshino S, Kunos G, Diehl A, Gao B: In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology 2003;125:202-15.
Sun R, Gao B: Negative regulation of liver regeneration by innate immunity (NK/IFN-g). Gastroenterology 2004;127:1525-39.
Radaeva R, Sun R, Pan H, Hong F, Gao B: Interleukin-22 (IL-22) plays a protective role in T cell hepatitis: IL-22 is a survival factor for hepatocytes via activation of STAT3. Hepatology 2004;39(5):1332-42.
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NIH Research and Training Opportunities
Updated: October 2005