CARe:
Candidate-gene Association Resource
The NHLBI initiated the Candidate gene Association
Resource (CARe) to create a shared genotype/phenotype
resource for analyses of the association of genotypes
with phenotypes relevant to the mission of the NHLBI.
The resource comprises nine cohort studies funded by
the NHLBI: Atherosclerosis Risk in Communities (ARIC),
Cardiovascular Health Study (CHS), Cleveland Family
Study (CFS), Coronary Artery Risk Development in Young
Adults (CARDIA), Cooperative Study of Sickle Cell Disease
(CSSCD), Framingham Heart Study (FHS), Jackson Heart
Study (JHS), Multi-Ethnic Study of Atherosclerosis (MESA),
and the Sleep Heart Health Study (SHHS). A database
of genotype and phenotype data will be created that
includes records for approximately 50,000 study participants
with approximately 50,000 SNPs from more than 1,200
selected candidate genes. In addition, a genome wide
association study using a 1,000K SNP Chip will be conducted
on approximately 9,500 African American participants
drawn from the 50,000 participants in the nine cohorts.
When completed, access to the CARe database will be
provided to the broad scientific community for research
purposes approved by the NHLBI Data Access Committee.
A single contract award was made to the Broad Institute
for they genotyping and bioinformatics center; Dr. Stacey
Gabriel is the Principal Investigator.
The NHLBI Program Officer for CARe is Richard
Fabsistz, Ph.D.
NHLBI
CARe Center Home Page
- ARIC - Atherosclerosis Risk in Communities
- CARDIA - Coronary Artery Risk Development in Young
Adults
- CFS - Cleveland Family Study
- CHS - Cardiovascular Health Study
- CSSCD - The Cooperative Study of Sickle Cell Disease
- FHS - Framingham Heart Study
- JHS - Jackson Heart Study
- MESA - Multi-Ethnic Study of Atherosclerosis
- SHHS - Sleep Heart Health Study
Program Start and End Date
April 2006 to March 2010
Large-Scale
Genotyping of NHLBI Cohorts 
RFP-HC-06-03 |
