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Vol. 6, No. 4
Jul–Aug 2000 
 

 


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荷兰高免疫人群中百日咳的再现:对监测资料的观测

Hester E. de Melker , J.F.P. Schellekens , S.E. Neppelenbroek , F.R. Mooi , H.C. Rumke, and M.A.E. Conyn-van Spaendonck
National Institute of Public Health and the Environment , Bilthoven , the Netherlands

 我们通过对1976年百日咳报告,死亡,住院治疗,和血清学资料的分析,来帮助我们了解荷兰1996年百日咳爆发的原因。这次意外的爆发是通过百日咳报告病例的增加和通过其它的监测方法检测到的。1996年据报告和血清学资料,在〈 1岁儿童中(多是未接受免疫的)百日咳发生率的增长情况与收住入院的病人增长情况相似。在高年龄人群中(多是接受过免疫的),入院者的增加数相对较小。在所有的年龄组中发生率的增加数在免疫人群中比未免疫人群要高.这导致了对疫苗有效率的过低估计。这种具感染症状的百日咳感染比例或许在免疫人群中已有所增长,这是因为疫苗菌株与传播的百日咳博代氏杆菌不匹配造成的。Dutch疫苗窄的免疫原性范围可能导致对B型百日咳杆菌抗原改变的更加不敏感。
  

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This page last reviewed January 02, 2003

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National Center for Infectious Diseases
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