Genetic Resources for Vision Researchers
NEIBank
A database of eye libraries and genes and proteins expressed in the eye and visual system maintained by the National Eye Institute (NEI)
NEIBank Executive Advisory Committee
Center for Inherited Disease Research (CIDR)
Genotyping and statistical genetics consultation services for investigators seeking to identify genes that contribute to human disease. NEI is one of twelve Institutes at the National Institutes of Health (NIH) that support the center.
Knockout Mice with Phenotypic Data
The NIH has contracted with Deltagen Inc. and Lexicon Genetics Incorporated to provide the research community with access to approximately 250 lines of knockout mice which have been extensively characterized. Investigators who receive the knockout mice lines are free to publish any results from research involving the lines and also to seek patent or other intellectual property protection for any inventions and/or discoveries resulting from such research.
Mutant Mice
The NIH has funded the isolation of mouse lines with selected genetic mutations affecting nervous system function and behavior. These are available through the Northwestern University Neurogenomics Project, the Tennessee Mouse Genome Consortium, and the Neuroscience Mutagenesis Facility at the Jackson Laboratories.
Neuroscience Microarray Consortium
In collaboration with the NIH Neurosciences Blueprint Initiative, the NEI is funding a consortium of four microarray centers to serve the expression profiling and SNP genotyping needs of NEI-funded ocular neuroscience investigators. The consortium has multiple microarray platforms available and can provide advice on experimental design. The consortium has laser-capture microdissection services, as well as data analysis, manuscript preparation, and training support. If your research program in neuroscience would benefit from expression profiling or SNP genotyping data, please consider using the services of the Neuroscience Microarray Consortium (http://arrayconsortium.tgen.org). For further information, please contact the consortium coordinator, Ms. Sarah Brautigam, at arrayconsortium@tgen.org or (602) 343-8732, or Dr. Hemin R. Chin, Ocular Genetics Program Director, NEI Division of Extramural Research, hemin@nei.nih.gov or 301-451-2020.
Genetic Association Information Network (GAIN)
The NIH and the Foundation for the NIH have established a public-private partnership to provide genome-wide genotyping in support of genome-wide association studies. Researchers may request access to the individual-level data from GAIN studies. See http://www.genome.gov/19518664 and http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-066.html.
Database of Genotype and Phenotype (dbGaP)
Researchers may request individual-level genotype and phenotype data. dbGaP entries include project datasets from the NEI-sponsored AREDS study, see http://grants.nih.gov/grants/guide/notice-files/NOT-EY-07-003.html
NIH Policy for Enhancing the Science, Safety, and Ethics of Recombinant DNA Research
The NIH has recent published a policy reminder at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-096.html.
Policy for Sharing of Data Obtained in NIH Supported or Conducted Genome-Wide Association Studies (GWAS)
This document address data sharing procedures, data access principles, intellectual property, and issues regarding the protection of research participants through all phases of GWAS. See http://grants.nih.gov/grants/guide/notice-pfiles/NOT-OD-07-088.html and http://grants.nih.gov/grants/guide/notice-files/NOT-OD-08-013.html
