Novel GPCR Signaling Paradigms in Animal Models |
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| Air date: | Wednesday, February 21, 2007, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Runtime: | 64 minutes |
| NLM Title: | Novel GPCR signaling paradigms in animal models [electronic resource] / Marc G. [i.e. Marc L.] Caron. |
| Series: | NIH director's Wednesday afternoon lecture series |
| Author: | Caron, Marc L. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | NIH director's Wednesday afternoon lecture series |
| Abstract: | (CIT): G protein-coupled receptors (GPCR) mediate numerous physiological responses. These responses are regulated by kinases (GRKs) followed by binding of the phosphorylated receptors to the scaffold protein, Betta-arrestin. This interaction not only dampens G protein-dependent signaling but also targets receptors for internalization and initiates additional signaling events through the ability of Betta-arrestin to scaffold signaling complexes. In the brain the dopaminergic system is presumably implicated in the control of locomotion, cognition and affect. In mice, activation of D2-like receptors modulates not only the cAMP-dependent signaling pathway but also engages an Akt/PP2A/GSK3 signaling pathway that is mediated by the ability of Betta-arrestin to scaffold these proteins. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. |
| Subjects: | Models, Animal Receptors, G-Protein-Coupled--physiology Signal Transduction--physiology |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | QU 55.7 |
| NLM ID: | 101300947 |
| CIT File ID: | 13647 |
| CIT Live ID: | 5189 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13647 |
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