Endocrine Section: Selected Recent Publications

• Gray, N, Arnold, JT, Liu, X. Blackman, MR 2009 Endocrine-Immune-Paracrine Interactions In Prostate Cells: A Model For Mechanistic Studies Of Phytomedicines (2009 : Cancer Prevention Research. Article highlighted in AACR Press Release.
• Arnold JT. DHEA metabolism in prostate: For better or worse? Mol Cell Endocrinol. 2008 Nov 1. [Epub ahead of print]
• Arnold JT, Gray NE, Jacobowitz K, Viswanathan L, Cheung PW, McFann KK, Le H, Blackman MR. Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells. J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):240–6. Epub 2008 Jun 22.
• Liu, X Allen, JD, Arnold, JT, Blackman, MR Lycopene inhibits IGF-I signal transduction and restores apoptosis in normal prostate epithelial cells by inhibiting DHT-modulated IGF-I production in cocultured reactive stromal cells. Carcinogenesis 2008 (4):816–23. Epub 2008 Feb 17
• Arnold, JT, Liu, X Allen, JD, Le H, McFann, KK, Blackman, MR. Androgen Receptor or Estrogen Receptor-beta Blockade alters DHEA-DHT- and E2-induced Proliferation and PSA production in human prostate cancer cells. Prostate. 2007 Aug 1;67(11):1152–62.
• Rao, JS, Ertley, RN, Lee, HJ, Demar Jr, JC, Arnold, JT, Rapoport, SI and Bazinet, RP, n-3 Polyunsaturated Fatty Acid Deprivation in Rats Decreases Frontal Cortex BDNF Via A p38 MAPK Dependent Mechanism, Mol Psychiatry. 2007 Jan;12(1):36–46
• Steele, VE,, Arnold, JT, Le, H, Izmirilian, G and Blackman, MR, 2006, Comparative Effects of DHEA and DHT on Gene Expression in Human LNCaP Prostate Cancer Cells, Anticancer Research, Vol 26:5A, pp. 3205–3216.
• Le, H, Arnold, JT, McFann, KK, Blackman, MR, 2006 Differential modulation of IGF-I, IGF Binding Protein 2 and IGFBP-3 Expression by Dihydrotestosterone and Testosterone in Primary Cultures of Human Prostatic Stromal Cells AmJ Physiol Endocrinol Metab 290(5):E952–60.
• Arnold, JT, Blackman, MR. 2005. Does Dehydroepiandrosterone exert direct effects on androgen and estrogen receptors, and does it promote or prevent prostate cancer? Endocrinology Vol. 146, No. 11 4565–4567. Invited Editorial.
• Arnold, JT, Le, H, McFann, KK, Blackman, MR<. 2005 Comparative effects of DHEA vs. testosterone, dihydrotestosterone, and estradiol on proliferation and gene expression in human LNCaP prostate cancer cells. Am J Physiol Endocrinol Metab. Mar; 288(3):E573–84.
• Dalrymple, S. Antony, L, Xu, Y, Uzgare, AR Arnold, JT, Savaugeot, J, Sokoll, LJ, De Marzo, AM and Isaacs JT. 2005 Role of Notch-1 and E-Cadherin in the Differential Response to Calcium in Culturing Normal versus Malignant Prostate, Cancer Res., 65: 9269–9279.
• Blackman MR, Muniyappa R, Wilson M, Moquin BE, Baldwin HL, Wong KA, Snyder C, Magalnick M, Alli S, Reynolds J, Steinberg SM, Goldbach-Mansky R. Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre-and perimenopausal women with active rheumatoid arthritis: a pilot case-control study. Arthritis Res Ther. 2007;9(4):R73.
• Khoromi S, Blackman MR, Kingman A, Patsalides A, Matheny LA, Adams S, Pilla AA, Max MB. Low intensity permanent magnets in the treatment of chronic lumbar radicular pain. J Pain Symptom Manage. 2007 Oct;34(4):434–45. Epub 2007 Jul 9.
• Muniyappa R, Sorkin JD, Veldhuis JD, Harman SM, Münzer T, Bhasin S, Blackman MR. Long-term testosterone supplementation augments overnight growth hormone secretion in healthy older men. Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E769–75.
• Manoli I, Alesci S, Blackman MR, Su YA, Rennert OM, Chrousos GP. Mitochondria as key components of the stress response. Trends Endocrinol Metab. 2007 Jul;18(5):190–8.
• Bai X, Wu J, Zhang Q, Alesci S, Manoli I, Blackman MR, Chrousos GP, Goldstein AL, Rennert OM, Su YA. Third-generation human mitochondria-focused cDNA microarray and its bioinformatic tools for analysis of gene expression. Biotechniques. 2007 Mar;42(3):365–75.
• Arnold JT, Blackman MR. Does DHEA exert direct effects on androgen and estrogen receptors, and does it promote or prevent prostate cancer? Endocrinology. 2005;146(11):4565–4567.
• Le H, Arnold JT, McFann KK, Blackman MR. Dihydrotestosterone and testosterone, but not DHEA or estradiol, diffrentially modulate IGF-I, IGFBP-2 and ICFBP-3 gene and protein expression in primary cultures of human prostatic stromal cells. American Journal of Physiology, Endocrinology and Metabolism. 2005.
• Blackman MR, Sorkin JD, Münzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O'Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell E, St Clair C, Pabst KM, Harman SM. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. Journal of the American Medical Association. 2002;288(18):2282–2292.
• Moffat SD, Zonderman AB, Metter EJ, Blackman MR, Harman SM, Resnick SM. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. Journal of Clinical Endocrinology and Metabolism. 2002;87(11):5001–5007.