Fact Sheet
TOXNET®:
Toxicology Data Network
TOXNET (TOXicology Data NETwork) is
a cluster of databases covering toxicology, hazardous chemicals, environmental
health and related areas. It is managed by the Toxicology and
Environmental Health Information Program (TEHIP) in the Division of Specialized Information Services
(SIS) of the National Library of Medicine
(NLM). TOXNET provides free access to and easy searching of the following
databases:
Toxicology Databases
- HSDB® (Hazardous
Substances Data Bank)
- A factual database focusing on the toxicology of over 4700 potentially
hazardous chemicals. In addition to toxicity data, HSDB provides information
in the areas of emergency handling procedures, industrial hygiene,
environmental fate, human exposure, detection methods, and regulatory
requirements. The data are fully referenced and peer-reviewed by a
Scientific Review Panel composed of expert scientists.
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- IRIS
(Integrated Risk Information System)
- A database from the U.S. Environmental
Protection Agency (EPA) containing carcinogenic and
non-carcinogenic health risk information on over 500 chemicals. IRIS risk
assessment data has been scientifically reviewed by EPA scientists and
represents EPA consensus.
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- ITER
(International Toxicity Estimates for Risk)
- This database contains data in support of human health risk assessments.
It is compiled by Toxicology Excellence for
Risk Assessment (TERA) and contains over 600 chemical records. ITER
provides a comparison of international risk assessment information in a
side-by-side format and explains differences in risk values derived by
different organizations. ITER data, focusing on hazard identification and
dose-response assessment, is extracted from each agency’s assessment and
contains links to the source documentation.
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- CCRIS (Chemical
Carcinogenesis Research Information System).
- A scientifically evaluated and fully referenced data bank, developed and
maintained by the National Cancer
Institute (NCI). It contains over 8000 chemical records with
carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test
results. Data are derived from studies cited in primary journals, current
awareness tools, NCI reports, and other special sources. Test results have
been reviewed by experts in carcinogenesis and mutagenesis.
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- GENE-TOX
(Genetic Toxicology)
- A toxicology database created by the U.S. Environmental Protection
Agency (EPA) containing genetic toxicology test results on over 3,000
chemicals. Selected literature was reviewed by scientific experts for
each of the test systems under evaluation; the results are represented in
GENE-TOX.
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- Tox Town
- An interactive guide to commonly encountered toxic substances, your
health, and the environment. It uses color, graphics, sounds and animation
to convey connections between chemicals, the environment, and the public's
health. Tox Town is designed to provide facts on toxic chemicals found in
everyday locations, information about how the environment can impact human
health, non-technical descriptions of chemicals, links to authoritative
chemical information on the Internet, and Internet resources on
environmental health topics. Tox Town's target audience is students above
elementary-school level, educators, and the general public. It is a
companion to the extensive information in the TOXNET collection of databases
that are typically used by toxicologists and health professionals. Tox Town
also offers some resources in Spanish (http://toxtown.nlm.nih.gov/espanol/).
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- Household Products Database
- This database provides information on the potential health effects of
chemicals contained in more than 4,000 common household products used inside
and around the home. The database allows users to browse a product category,
such as 'Pesticides' or 'Personal Care,' by alphabetical listing of brand
names. Products can also be searched by type, manufacturer, product
ingredient/chemical name and by health effects. The record for each product
shows the ingredients as reported in the manufacturer's Material Safety Data
Sheet (MSDS) and includes other information such as handling, disposal, and
health effects.
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- Haz-Map®
- An occupational toxicology database designed primarily for health and
safety professionals, but also for consumers seeking information about the
health effects of exposure to chemicals at work. It links jobs and
hazardous tasks with occupational diseases and their symptoms. The
approximately 1,000 chemicals and biological agents in the database are
related to industrial processes and other activities such as hobbies.
The linkage indicates the potential for exposure to the agents. The
180 occupational diseases and their symptoms are associated with hazardous
job tasks. This association indicates an increased risk for
significant exposure and subsequent disease.
The TOXNET "Multiple Databases" option allows for simultaneous searching of
HSDB, IRIS, CCRIS, and GENE-TOX.
Toxicology Literature
- TOXLINE®
- A bibliographic database providing comprehensive coverage of the
biochemical, pharmacological, physiological, and toxicological effects of
drugs and other chemicals from 1965 to the present. TOXLINE contains over 3
million citations, almost all with abstracts and/or index terms and CAS
Registry Numbers. TOXLINE references are drawn from sources grouped into two
major parts, TOXLINE Core
and TOXLINE
Special, both of which offer a variety of search and display
capabilities.
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- DART®/ETIC
(Development and Reproductive Toxicology/Environmental Teratology Information
Center)
- A bibliographic database covering literature on reproductive and
developmental toxicology. DART is managed by NLM and funded by the EPA, the
National Institute of Environmental
Health Sciences (NIEHS) and NLM. DART/ETIC contains over 200,000
references to reproductive and developmental toxicology literature published
since 1965.
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- Toxics Release
Inventory (TRI)
- A series of databases that describe the releases of toxic chemicals into
the environment annually for the 1987-2001 reporting years. TRI is mandated
by the Emergency Planning and Community Right-to-Know Act and is based on
data submitted to the EPA from industrial facilities throughout the U.S.
These data include the names and addresses of those facilities, and the
amounts of certain toxic chemicals they release to the air, water, or land,
or transfer to waste sites. Information is included on over 650 chemicals
and chemical categories. Pollution prevention data are also reported by each
facility for each chemical.
Chemical Information
- ChemIDplus
- A database providing access to structure and nomenclature authority
databases used for the identification of chemical substances cited in NLM
databases. ChemIDplus contains over 367,000 chemical records, of which over
200,000 include chemical structures. ChemIDplus is searchable by Name,
Synonym, CAS Registry Number, Molecular Formula, Classification Code,
Locator Code, and Structure. A new ChemIDplus Lite version
is available for Name and RN searching without the need for plugins or
applets.
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- NCI-3D
- A database of over 213,000 substances with 2D and 3D information
compiled from the National Cancer Institute (NCI).
Web Access/Searching
TOXNET databases are accessible free of charge at: http://toxnet.nlm.nih.gov/
TOXNET's web interface is designed as an easy way to search databases of
varying formats and content. It can be used to locate toxicology data,
literature references, and toxic release information on particular chemicals as
well as to search to identify chemicals that cause specific effects. TOXNET
offers a variety of ways to display and sort information. Its "Multi-Databases"
feature provides an integrated search of any or all of several databases (HSDB,
IRIS, CCRIS, GENE-TOX). Its "Search All Databases" feature provides a list of
TOXNET databases in which a search term is found, each paired with the retrieval
record count and with links to the Search Results page of those
databases.
Links are available from TOXNET to PubMed®, NLM's free web interface to the
world's biomedical literature, and to additional sources of toxicological
information.
Further Information
For detailed information on TOXNET, contact:
Specialized Information
Services
National Library of Medicine
Two Democracy Plaza, Suite
510
6707 Democracy Boulevard, MSC 5467
Bethesda, MD
20892-5467
Telephone: (301) 496-1131
e-mail:
tehip@teh.nlm.nih.govURL:
http://sis.nlm.nih.gov/
For general information on the Library's computerized information services,
including TOXNET, contact:
National Library of Medicine
Customer Service
8600 Rockville
Pike
Bethesda, MD 20894
Telephone: 1-888-FINDNLM
(1-888-346-3656)
e-mail: custserv@nlm.nih.gov
A complete list of NLM Fact Sheets is available
at:
(alphabetical list) http://www.nlm.nih.gov/pubs/factsheets/factsheets.html
(subject
list): http://www.nlm.nih.gov/pubs/factsheets/factsubj.html
Or write to:
FACT SHEETS
Office of Communications and Public Liaison
National
Library of Medicine
8600 Rockville Pike
Bethesda, Maryland 20894
Phone: (301) 496-6308
Fax: (301) 496-4450
email: publicinfo@nlm.nih.gov